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R&D Roundup: Ultrasound/AI medical imaging, assistive exoskeletons and neural weather modeling

In the time of COVID-19, much of what transpires from the science world to the general public relates to the virus, and understandably so. But other domains, even within medical research, are still active — and as usual, there are tons of interesting (and heartening) stories out there that shouldn’t be lost in the furious activity of coronavirus coverage. This last week brought good news for several medical conditions as well as some innovations that could improve weather reporting and maybe save a few lives in Cambodia.

Ultrasound and AI promise better diagnosis of arrhythmia

Arrhythmia is a relatively common condition in which the heart beats at an abnormal rate, causing a variety of effects, including, potentially, death. Detecting it is done using an electrocardiogram, and while the technique is sound and widely used, it has its limitations: first, it relies heavily on an expert interpreting the signal, and second, even an expert’s diagnosis doesn’t give a good idea of what the issue looks like in that particular heart. Knowing exactly where the flaw is makes treatment much easier.

Ultrasound is used for internal imaging in lots of ways, but two recent studies establish it as perhaps the next major step in arrhythmia treatment. Researchers at Columbia University used a form of ultrasound monitoring called Electromechanical Wave Imaging to create 3D animations of the patient’s heart as it beat, which helped specialists predict 96% of arrhythmia locations compared with 71% when using the ECG. The two could be used together to provide a more accurate picture of the heart’s condition before undergoing treatment.

Another approach from Stanford applies deep learning techniques to ultrasound imagery and shows that an AI agent can recognize the parts of the heart and record the efficiency with which it is moving blood with accuracy comparable to experts. As with other medical imagery AIs, this isn’t about replacing a doctor but augmenting them; an automated system can help triage and prioritize effectively, suggest things the doctor might have missed or provide an impartial concurrence with their opinion. The code and data set of EchoNet are available for download and inspection.

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Nectar’s sonar bottle caps could save $50B in stolen booze

Bars lose 20% of their alcohol to overpours and “free” drinks for friends. That amounts to $50 billion per year in booze that mysteriously disappears, making life tough for every pub and restaurant. Nectar wants to solve that mystery with its ultrasound depth-sensing bottle caps that measure how much liquid is left in a bottle by measuring how long it takes a sonar pulse to bounce back. And now it’s bringing real-time pour tracking to beer with its gyroscopic taps. The result is that bar managers can determine who’s pouring too much or giving away drink, which promotions are working and when to reorder bottles without keeping too much stock on hand — and avoid wasting hours weighing or eyeballing the liquor level of their inventory.

Nectar’s solution to alcohol shrinkage has now attracted a $10 million Series A led by DragonCapital.vc and joined by former Campari chairman Gerry Ruvo, who will join the board. “Not a lot of technology has come to the bottle,” Nectar CEO Aayush Phumbhra says of ill-equipped bars and restaurants. “Liquor is their highest margin and highest cost item. If you don’t manage it efficiently, you go out of business.” Other solutions can look ugly to customers, forcibly restrict bartenders or take time and money to install and maintain. In contrast, Phumbhra tells me, “I care about solving deep problems by building a solution that doesn’t change behavior.”

Investors were eager to back the CEO, since he previously co-founded text book rental giant Chegg — another startup disrupting an aged market with tech. “I come from a pretty entrepreneurial family. No one in my family has ever worked for anyone else before,” Phumbhra says with a laugh. He saw an opportunity in the stunning revelation that the half-trillion-dollar on-premises alcohol business was plagued by missing booze and inconsistent ways to track it.

Typically at the end of a week or month, a bar manager will have staff painstakingly look at each bottle, try to guess what percent remains and mark it on a clipboard to be loaded into a spreadsheet later. While a little quicker, that’s very subjective and inaccurate. More advanced systems see every bottled weighed to see exactly how much is left. If they’re lucky, the scale connects to a computer, but they still have to punch in what brand of booze they’re sizing up. But the process can take many hours, which amounts to costly labor and infrequent data. None of these methods eliminate the manual measurement process or give real-time pour info.

So with $6 million in funding, Nectar launched in 2017 with its sonar bottle caps that look and operate like old-school pourers. When bars order them, they come pre-synced and labeled for certain bottle shapes like Patron or Jack Daniels. Their Bluetooth devices stay charged for a year and connect wirelessly to a base hub in the bar. With each pour, the sonar pulse determines how much is in the bottle and subtracts it from the previous measurement to record how much was doled out. And the startup’s new gyroscopic beer system is calibrated to deduce pour volume from the angle and time the tap is depressed without the need for a sensor to be installed (and repaired) inside the beer hose.

Bar managers can keep any eye on everything throughout the night with desktop, iOS and Android apps. They could instantly tell if a martini special is working based on how much gin across brands is being poured, ask bartenders to slow their pours if they’re creeping upwards in volume or give the green light to strong pours on weeknights to reward regular customers. “Some bars encourage overpours to get people to keep coming back,” says local San Francisco celebrity bartender Broke-Ass Stuart, who tells me pre-measured pourers can save owners money but cost servers tips.

Nectar now sells self-serve subscriptions to its hardware and software, with a 20-cap package costing $99 per month billed annually with free yearly replacements. It’s also got a free two-tap trial package, or a $399 per month enterprise subscription for 100 taps. Nectar is designed to complement bar point of sale systems. And if a bar just wants the software, Nectar just launched its PrecisionAudit app, where staff tap the current liquid level on a photo of each different bottle for more accurate eyeballing. It’s giving a discount rate of $29.99 per month on the first 1,000 orders.

After 2 million pours measured, the business is growing 200% quarter-over-quarter as bowling alley chains and stadiums sign up for pilots. The potential to change the booze business seduced investors like Tinder co-founders Sean Rad and Justin Mateen, Palantir co-founder Joe Lonsdale and the founding family of the Modelo beer company. Next, Nectar is trying to invent a system for wine. That’s trickier, as its taps would need to be able to suck the air out of the bottles each night.

The big challenge will be convincing bars to change after tracking inventory the same way for decades. No one wants to deal with technical difficulties in a jam-packed bar. That’s partly why Nectar’s subscription doesn’t force owners to buy its hardware up front.

If Nectar can nail not only the tech but the bartender experience, it could pave a smoother path to hospitality entrepreneurship. Alcohol shrinkage is one factor leading to the rapid demise of many bars and restaurants. Plus, it could liberate bartenders from measuring bottles into the wee hours. As Phumbhra noted, “They’re coming in on weekends and working late. We want them to spend that time with their families and on customer service.”

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Kindbody raises $15M, will open a ‘Fertility Bus’ with mobile testing & assessments

Kindbody, a startup that lures millennial women into its pop-up fertility clinics with feminist messaging and attractive branding, has raised a $15 million Series A in a round co-led by RRE Ventures and Perceptive Advisors.

The New York-based company was founded last year by Gina Bartasi, a fertility industry vet who previously launched Progyny, a fertility benefit solution for employers, and FertilityAuthority.com, an information platform and social network for people struggling with fertility.

“We want to increase accessibility,” Bartasi told TechCrunch. “For too long, IVF and fertility treatments were for the 1 percent. We want to make fertility treatment affordable and accessible and available to all regardless of ethnicity and social economic status.”

Kindbody operates a fleet of vans — mobile clinics, rather — where women receive a free blood test for the anti-Müllerian hormone (AMH), which helps assess their ovarian egg reserve but cannot conclusively determine a woman’s fertility. Depending on the results of the test, Kindbody advises women to visit its brick-and-mortar clinic in Manhattan, where they can receive a full fertility assessment for $250. Ultimately, the mobile clinics serve as a marketing strategy for Kindbody’s core service: egg freezing.

Kindbody charges patients $6,000 per egg-freezing cycle, a price that doesn’t include the cost of necessary medications but is still significantly less than market averages.

Bartasi said the mobile clinics have been “wildly popular,” attracting hoards of women to its brick-and-mortar clinic. As a result, Kindbody plans to launch a “fertility bus” this spring, where the company will conduct full fertility assessments, including the test for AMH, a pelvic ultrasound and a full consultation with a fertility specialist.

In other words, Kindbody will offer all components of the egg-freezing process on a bus aside from the actual retrieval, which occurs in Kindbody’s lab. The bus will travel around New York City before heading west to San Francisco, where it plans to park on the campuses of large employers, catering to tech employees curious about their fertility.

“Our mission at Kindbody is to bring care directly to the patient instead of asking the patient to come to visit us and inconvenience them,” Bartasi said.

A sneak peek of Kindbody’s “fertility bus,” which is still in the works

Kindbody, which has raised $22 million to date from Green D Ventures, Trailmix Ventures, Winklevoss Capital, Chelsea Clinton, Clover Health co-founder Vivek Garipalli and others, also provides women support getting pregnant with in vitro fertilisation (IVF) and intrauterine insemination (IUI). 

With the latest investment, Kindbody will open a second brick-and-mortar clinic in Manhattan and its first permanent clinic in San Francisco. Additionally, Bartasi says they are in the process of closing an acquisition in Los Angeles that will result in Kindbody’s first permanent clinic in the city. Soon, the company will expand to include mental health, nutrition and gynecological services.

In an interview with The Verge last year, Bartasi said she’s taken inspiration from SoulCycle and DryBar, companies whose millennial-focused branding strategies and prolific social media presences have helped them accumulate customers. Kindbody, in that vein, notifies its followers of new pop-up clinics through its Instagram page.

In the article, The Verge called Kindbody “the SoulCycle of fertility” and questioned its branding strategy and its claim that egg freezing “freezes time.” After all, there is limited research confirming the efficacy of egg freezing.

“The technology that allows for egg-freezing has only been widely used in the last five to six years,” Bartasi explained. “The majority of women who froze their eggs haven’t used them yet. It’s not like you freeze your eggs in February and meet Mr. Right in June.”

Though Kindbody touts a mission of providing fertility treatments to the 99 percent, there’s no getting around the sky-high costs of the services, and one might argue that companies like Kindbody are capitalizing off women’s fear of infertility. Providing free AMH tests, which often falsely lead women to believe they aren’t as fertile as they’d hoped, might encourage more women to seek a full-fertility assessment and ultimately, to pay $6,000 to freeze their eggs, when in reality they are just as fertile as the average woman and not the ideal candidate for the difficult and uncomfortable process.

Bartasi said Kindbody makes all the options clear to its patients. She added that when she does hear accusations that services like Kindbody capitalize on fear of infertility, they tend to come from legacy programs and male fertility doctors: “They are a little rattled by some of the new entrants that look like the patients,” she said. “We are women designing for women. For far too long women’s health has been solved for by men.”

Kindbody’s pricing scheme may itself instill fear in incumbent fertility clinics. The startup’s egg-freezing services are much cheaper than market averages; its IVF services, however, are not. Not including the costs of medications necessary to successfully harvest eggs from the ovaries, the average cost of an egg-freezing procedure costs approximately $10,000, compared to Kindbody’s $6,000. Its IVF services are on par with other options in the market, costing $10,000 to $12,000 — not including medications — for one cycle of IVF.

Kindbody is able to charge less for egg freezing because they’ve cut out operational inefficiencies, i.e. they are a tech-enabled platform while many fertility clinics around the U.S. are still handing out hoards of paperwork and using fax machines. Bartasi admits, however, that this means Kindbody is making less money per patient than some of these legacy clinics.

“What is a reasonable profit margin for fertility doctors today?” Bartasi said. “Historically, margins have been very, very high, driven by a high retail price. But are these really high retail prices sustainable long term? If you’re charging 22,000 for IVF, how long is that sustainable? Our profit margins are healthy.”

Bartasi isn’t the only entrepreneur to catch on to the opportunity here, as I’ve noted. A whole bunch of women’s health startups have launched and secured funding recently.

Tia, for example, opened a clinic and launched an app that provides health advice and period tracking for women. Extend Fertility, which like Kindbody, helps women preserve their fertility through egg freezing, banked a $15 million round. And a startup called NextGen Jane, which is trying to detect endometriosis with “smart tampons,” announced a $9 million Series A a few weeks ago.

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Watch Ultrahaptics use ultrasound to let you feel imaginary objects

 Ultrahaptics lets you touch what you see in virtual and augmented reality, or even give a 2D poster 3D feeling. It uses small speaker-like ultrasound wave emitters to give the sensation of pressure and texture when you’re just waving your hands in the open air. Ultrahaptics CTO Tom Carter demoed the technology onstage today at TechCrunch’s Disrupt Berlin conference.  Read More

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uBeam’s Ultrasound Wireless Charging Is Real, And About To Be Really Funded

power-cord What if wireless power at a distance actually worked? It does. uBeam invented a way to wirelessly send energy up to 15 feet away with ultrasound. What if you could slap a wireless charging case on your phone and charge it while you move around or use it? uBeam invented that too. While early uBeam prototype were massive, non-portable boxes that merely shot power around, it now has a working… Read More

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