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This Y Combinator startup is taking lab-grown meat upscale with elk, lamb and Wagyu beef cell lines
Last week a select group of 20 employees and guests gathered at an event space on the San Francisco Bay, and, while looking out at the Bay Bridge, dined on a selection of choice elk sausages, Wagyu meatloaf and lamb burgers — all of which were grown from a petri dish.
The dinner was a coming out party for Orbillion Bio, a new startup pitching today in Y Combinator’s latest demo day, that’s looking to take lab-grown meats from the supermarket to high-end, bespoke butcher shops.
Instead of focusing on pork, chicken and beef, Orbillion is going after so-called heritage meats — the aforementioned elk, lamb and Wagyu beef to start.
By focusing on more expensive-end products, Orbillion doesn’t have as much pressure to slash costs as dramatically as other companies in the cellular meat market, the thinking goes.
But there’s more to the technology than its bougie beef, elite elk and luscious lamb meat.
“Orbillion uses a unique accelerated development process producing thousands of tiny tissue samples, constantly iterating to find the best tissue and media combinations,” according to Holly Jacobus, whose firm, Joyance Partners, is an early investor in Orbillion. “This is much less expensive and more efficient than traditional methods and will enable them to respond quickly to the impressive demand they’re already experiencing.”
The company runs its multiple cell lines through a system of small bioreactors. Orbillion couples that with a high throughput screening and machine learning software system to build out a database of optimized tissue and media combinations. “The key to making lab grown meat work scalably is choosing the right cells cultured in the most efficient way possible,” Jacobus wrote.
Orbillion is co-founded by a deeply technical and highly experienced team of executives that’s led by Patricia Bubner, a former researcher at the German pharmaceutical giant Boehringer Ingelheim. Joining Bubner is Gabriel Levesque-Tremblay, a former director of the American Institute of Chemical Engineers, who was a post-doc at Berkeley with Bubner and serves as the company’s chief technology officer. Rounding out the senior leadership is Samet Yildirim, the chief operating officer and a veteran executive of Boehringer Ingelheim (he actually served as Bubner’s boss).
Orbillion Bio co-founders Gabriel Levesque-Tremblay, CTO; Patricia Bubner, CEO; and Samet Yildirim, COO. Image Credit: Orbillion Bio
For Bubner, the focus on heritage meats is as much a function of her background growing up in rural Austria as it is about economics. A longtime, self-described foodie and a nerd, Bubner went into chemistry because she ultimately wanted to apply science to the food business. And she wants Orbillion to make not just meat, but the most delicious meats.
It’s an aim that fits with how many other companies have approached the market when they’re looking to commercialize a novel technology. Higher-end products, or products with unique flavor profiles that are unique to the production technologies available, are more likely to be commercially viable sooner than those competing with commodity products. Why focus on angus beef when you can focus on a much more delicious breed of animal?
For Bubner, it’s not just about making a pork replacement, it’s about making the tastiest pork replacement.
“I’m just fascinated and can see the future in us being able to further change the way we produce food to be more efficient,” she said. “We’re at this inflection point. I’m a nerd, I’m a foodie, and I really wanted to use my skills to make a change. I wanted to be part of that group of people that can really have an impact on the way we eat. For me there’s no doubt that a large percentage of our food will be from alternative proteins — plant based, fermentation and lab-grown meat.”
Joining Boehringer Ingelheim was a way for Bubner to become grounded in the world of big bioprocessing. It was preparation for her foray into lab-grown meat, she said.
“We are a product company. Our goal is to make the most flavorful steaks. Our first product will not be whole cuts of steak. The first product is going to be a Wagyu beef product that we plan on putting out in 2023,” Bubner said. “It’s a product that’s going to be based on more of a minced product. Think Wagyu sashimi.”
To get to market, Bubner sees the need not just for a new approach to cultivating choice meats, but a new way of growing other inputs as well, from the tissue scaffolding needed to make larger cuts that resemble traditional cuts of meat, or the fats that will need to be combined with the meat cells to give flavor.
That means there are still opportunities for companies like Future Fields, Matrix Meats and Turtle Tree Scientific to provide inputs that are integrated into the final, branded product.
Bubner’s also thinking about the supply chain beyond her immediate potential partners in the manufacturing process. “Part of my family were farmers and construction workers and the others were civil engineers and architects. I hold farmers in high respect… and think the people who grow the food and breed the animals don’t get recognition for the work that they do.”
She envisions working in concert with farmers and breeders in a kind of licensing arrangement, potentially, where the owners of the animals that produce the cell lines can share in the rewards of their popularization and wider commercial production.
That also helps in the mission of curbing the emissions associated with big agribusiness and breeding and raising livestock on a massive scale. If you only need a few animals to make the meat, you don’t have the same environmental footprint for the farms.
“We need to make sure that we don’t make the mistakes that we did in the past that we only breed animals for yield and not for flavor,” said Bubner.
Even though the company is still in its earliest days, it already has one letter of intent, with one of San Francisco’s most famous butchers. Guy Crims, also known as “Guy the Butcher,” has signed a letter of intent to stock Orbillion Bio’s lab-grown Wagyu in his butcher shop, Bubner said. “He’s very much a proponent of lab-grown meat.”
Now that the company has its initial technology proven, Orbillion is looking to scale rapidly. It will take roughly $3.5 million for the company to get a pilot plant up and running by the end of 2022, and that’s in addition to the small $1.4 million seed round the company has raised from Joyant and firms like VentureSouq.
“The way I see an integrated model working later on is to have the farmers be the breeders of animals for cultivated meat. That can reduce the number of cows on the planet to a couple of hundred thousand,” Bubner said of her ultimate goal. “There’s a lot of talking about if you do lab-grown meat you want to put me out of business. It’s not like we’re going to abolish animal agriculture tomorrow.”
Image Credit: Getty Images
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Higher Steaks brings home the bacon, revealing lab-grown pork belly and bacon strips
In what could be a starting gun for the commercialization of the cell-based meat business, upstart cultivated meat company Higher Steaks said it has managed to produce samples of its first products — bacon strips and pork belly made in a lab from cellular material.
With the revelation, Higher Steaks, a bootstrapped Cambridge, U.K.-based company, leapfrogs into a competitive position with a number of far larger companies that have raised far more capital.
“There’s still a lot of work until it’s commercial,” said Higher Steaks chief executive Benjamina Bollag, “but the revelation of a pork belly product that’s made from 50% cultivated cells and a bacon product which contains 70% meat grown from a cell material in a laboratory is something of a milestone for the industry.”
The remaining ingredients in Higher Steaks bacon and pork belly are a mixture of plant base, proteins, fats and starches to bind the cellular material together. To achieve this first step on its road to commercialization, Higher Steaks tapped the expertise of an undisclosed chef to formulate the meat into an approximation of the pork belly and bacon.
Higher Steaks head of research and development, Ruth Helen Faram (left) and chief executive Benjamina Bollag (right) Image Credits: Higher Steaks (opens in a new window)
At this stage, the pilot was more to show what Higher Steaks can do rather than what the company will do, said Bollag.
“In the future it will be scaffolding,” said Bollag. “It’s more showing what our meat can do and what we’re working on. In the future it will be with scaffolding.”
A number of companies, including Tantti Laboratories, Matrix Meats and Prellis Biologics, make the kind of biomaterial nano-scale scaffolding that could be used as a frame on which to grow structures equivalent to the fibrous textures of muscle.
The commercial viability of products from companies like Higher Steaks, Memphis Meats, Aleph Farms, Meatable, Integriculture, Mosa Meat and Supermeat depends on more than just companies like Tantti and Matrix, but also on the ability of Thermo Fisher, Future Fields and Merck to bring down the cost of the cell cultures that are required to grow the animal cells.
In all, some 30 cell-based meat startups have launched globally since 2014, and they’re all looking for a slice of the $1.4 trillion meat market.
Meanwhile, demand for pork continues to rise even as supplies have been decimated by an outbreak of African Swine Fever that could have killed as much as 40% of China’s population of pigs in 2019.
“Our mission is to provide meat that is healthy and sustainable without the consumer making any sacrifices on taste,” said Bollag in a statement. “The production of the first ever cultivated bacon and pork belly is proof that new techniques can help meet overwhelming demand for pork products globally.”
Given the highly capitalized competitors that Higher Steaks faces off against, the company is looking for industry partners to help commercialize its technology.
To improve its competitive position, Higher Steaks recently hired Dr. James Clark, the former chief technology officer of PredictImmune.
“I was always quite intrigued by cultured meat production, a mix of both science and food production. In 2013 I watched the first cultured meat burger from Mark Post costing £250,000, cooked on the BBC,” said Clark. “I was approached about joining Higher Steaks earlier this year and was attracted to joining primarily by the science along with the ambition and energy of the Higher Steaks founder Benjamina Bollag . I believe Higher Steaks is a company with a technology to be disruptive in the cultured meat area and at my career stage I was looking for a challenge.”
Brought in to scale the cultivated meat process at Higher Steaks, Clark has led the development of biotech and pharma products at early-stage and publicly traded companies.
“The addition of Dr. James Clark to the team gives Higher Steaks a significant advantage,” said Dr. Ruth Helen Faram, head of R&D. “Cultivated pork belly and bacon have never been demonstrated before and Higher Steaks is the first to develop a prototype containing over 70% cultivated pork muscle, without the use of bovine serum.”
Consumers shouldn’t expect to see Higher Steaks’ pork belly on store shelves or in restaurants anytime soon, Bollag cautioned. “We’re still in the thousands of pounds per kilogram.”
The company does expect to have a larger tasting event later this year.
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Dutch startup Meatable is developing lab-grown pork and has $10 million in new financing to do it
Meatable, the Dutch startup developing cruelty-free technologies for manufacturing cultured meat, is pivoting to pork production as a swine flu epidemic ravages one quarter of the world’s pork supply — and has raised $10 million in financing to support its new direction.
When the company unveiled its technology last year, it was one of several companies working on the production of meat derived from animal cells — a method of meat production that theoretically has a far smaller carbon emissions footprint and is better for the environment than traditional animal farming.
At the time, it was one of several companies — including Memphis Meats, Future Meat Technologies, Aleph Farms, HigherSteaks and many, many pursuing technologies — to bring cultured beef to market. Now, as pork prices rise globally, Meatable becomes one of the first companies to publicly shift gears and turn its attention to the other white meat.
That’s not the only way the company is setting itself apart from its peers in the market. Meatable is also an early claimant to a commercially viable, patented process for manufacturing meat cells without the need to kill an animal as a prerequisite for cell differentiation and growth.
Other companies have relied on fetal bovine serum or Chinese hamster ovaries to stimulate cell division and production, but Meatable says it has developed a process where it can sample tissue from an animal, revert that tissue to a pluripotent stem cell, then culture that cell sample into muscle and fat to produce the pork products that palates around the world crave.
“We know which DNA sequence is responsible for moving an early-stage cell to a muscle cell,” says Meatable chief executive Krijn De Nood.
To pursue its new path, the company has raised $7 million from a slew of angel and institutional investors and a $3 million grant from the European Commission . Angel investors include Taavet Hinrikus, the chief executive and co-founder of TransferWise, and Albert Wenger, a managing partner at the New York-based venture firm Union Square Ventures.
Meatable’s De Nood says that the new cash will be used to accelerate the development of its prototype. The small-scale bioreactor the company had initially targeted for development in 2021 will now be ready by 2020 and the company is hoping to have an industry-scale plant online manufacturing thousands of kilograms of meat by 2025, according to De Nood.
Industrial farming is responsible for between 14% and 18% of the greenhouse gas emissions linked to global climate change and Meatable argues that cultured (lab-grown) meat has the potential to use 96% less water and 99% less land than industrial farming. Powering facilities using renewable energy could further reduce emissions associated with meat production, according to Meatable.
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