science
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In 1998, the startup company Illumina launched a revolution in the life sciences industry by developing technology to slash the costs of identifying and mapping genetic material.
Now, a little over 20 years later, Mammoth Biosciences is hoping to do the same thing for gene editing tools.
The company, co-founded by Jennifer Doudna, who did some of the pioneering work to discover the gene editing enzyme known as CRISPR, has just raised $45 million as it looks to bring to market products that can be used not only for disease detection, but are more precise editing tools for genetic material.
Rather than get bogged down in the patent dispute that raged over the provenance and ownership of applications for the original CRISPR enzyme — the Cas9 discovered by Doudna and developed for clinical applications at the Broad Institute — Mammoth has joined a number of startups in identifying new enzymes with a broader array of properties.
“From the very beginning of the company we’ve only worked with novel new enzymes to create these diagnostic products and the new novel diagnostic and editing,” says Trevor Martin, Mammoth Biosciences co-founder and chief executive.
Chiefly, the company is touting its Cas14 enzyme, which the company says opens up new possibilities for programmable biology thanks to its small size, diverse targeting ability and high fidelity — meaning that there are no unforeseen side effects to edits made using the enzyme (something that has arisen with Cas9 applications).
“There’s not one protein that’s going to be the best at everything,” says Martin. “For any particular product that you’re building, at Mammoth, we have the broadest toolbox.”
The Cas14 enzyme can be used to make gene edits in-vivo, meaning in live organisms, instead of ex-vivo, or outside of an organism. The in-vivo use-case could accelerate the time it takes to conduct experiments or develop treatments.
“Twenty years from now, when the umpteenth drug gets approved using Crispr and some nuclease named Cas132013, people are going to look back on this patent battle and think, ‘what a godawful waste of money,’ ” Jacob Sherkow a patent law scholar at New York Law School told Wired back in 2018.
Already, Horizon Discovery, a Cambridge, U.K.-based gene editing technology developer, is using the new tools developed by Mammoth Bioscience to create new CRISPR tools for Chinese Hamster Ovary cell line editing.
That partnership is an example of how Mammoth is thinking about the commercialization of the new Cas14 enzyme line and its role in biological engineering.
“You will need a full toolbox of CRISPR proteins,” says Martin. “That will allow you to interact with biology in the same way that we interact with software and computers. “From first principles, companies will programmatically modify biology to cure a disease or decrease risk for a disease. That’s going to be really kind of a turning point.”
To achieve its vision, Mammoth has managed to nab top talent from the life sciences industry, including Peter Nell, a co-founder of Casebia (a joint venture between Bayer and CRISPR Therapeutics), who came on board as chief business officer, and Ted Tisch, a former executive at Synthego and Bio-Rad, who joined the company as chief operating officer.
The company also nabbed $45 million of funding, including investment firms Mayfield, NFX, Verily (the Alphabet subsidiary) and Brook Byers, which was led by Decheng Capital — bringing the company to more than $70 million in funding.
“There are a dozen or so products that are in clinical development with CRISPR,” says Ursheet Parikh, a partner with Mayfield. “Maybe that number would go up by five or 10 without Mammoth, but it will go up by one or two orders of magnitude with Mammoth.”
To Parikh, Mammoth is the best positioned of the CRISPR development tools, because the company is building a whole platform that customers can license and use to develop products using gene editing.
The thinking, according to Parikh, is as follows, “if this technology can power lots of applications, let’s basically ensure that lots of these applications can come to market and as that happens I get my app store cut.”
“It’s an Illumina-like business,” Parikh says. “Just as anybody who is innovating with genomics needs an Illumina sequencer because they want to be able to do the sequencing… if someone wants to do editing… This gives them the access to do the right sequencing.”
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NASA has selected Houston-based Axiom Space, a startup founded in 2016, to build the first commercial habitat module for the International Space Station (ISS). This module will be used as a destination for future commercial spaceflight missions, potentially housing experiments, technology development and more performed by commercial space travelers taking rides up to the ISS via human-rated spacecraft like the SpaceX Crew Dragon and Boeing Starliner, once those start regular operational service.
Axiom Space was founded in 2016, and is led by co-founder and CEO Michael T. Suffredini, who previously acted as program manager for the ISS at NASA’s Johnson Space Center. The company boasts a lot of ex-NASA talent on its small team, and eventually it plans to make its in-space modules the basis of its own private space station, after first attaching them to the ISS while it’s still operating. NASA has extended the planned service life of the ISS, but the plan of the agency’s current leadership is to eventually encourage private orbital labs and commercial facilities as an ultimate replacement.
In 2018, Axiom teamed up with designer Philippe Starck (yes, the same one who famously designed a luxury yacht for Apple founder Steve Jobs) to provide a look at what their future space station modules might look like, including crew quarters with interactive displays and a cupola that provides a breathtaking view of Earth and surrounding space.

This ISS module may not be a full-fledged private space station, but it is a step in NASA’s goal of further commercializing the existing space station and ultimately paving the way for more commercial activity in low Earth orbit. Axiom’s mandate also includes providing “at least one habitable commercial module,” with the implication being that it might be awarded extensions to build more in the future. Next up for the new partners is negotiating terms and price for a contract for the module, which will also include a timeline for delivery.
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Plenty of the ocean remains unexplored, even though it’s a huge trove of potentially valuable information. Current methods for mapping and gathering ocean data, especially deep-ocean data, generally require humans in the mix (even if controlling vehicles remotely), are immensely expensive and are not designed for long periods of operation. Startup Terradepth, founded by two ex-Navy SEALs and based in Austin, Texas, is aiming to change all that using autonomous submersible vehicles that can, if deployed as a fleet with adequate scale, provide access to deep-ocean information on a data-as-a-service basis.
The startup has raised $8 million in funding in a new round led by storage hardware company Seagate Technology, and the funding will help it pursue its ambitious goal of demonstrating their technology at work in an open-water environment by next summer. From there, it hopes to scale its operations the following year, and ultimately operate an entire networked fleet of its fully autonomous underwater robots, which it calls “Autonomous Hybrid Vehicles,” or AxV.
Terradepth says that its technology will be able to operate at a scale and cost not previously possible because of their use of autonomous navigation, and it will aim to offer raw data, information processed through their own machine-learning powered analytics layer, or cloud-based third-party analytics. They aim to offer multispectral imaging, surveillance and monitoring/forecasting services for off-shore equipment and resources.
In addition to co-founders Joe Wolfel and Judson Kauffman, Terradepth’s small team includes a range of roboticists and engineers with expertise in both software and hardware. Their vehicles are designed to alternate between deep ocean passes and trips to the water’s surface, with underwater AxV communicating with the surface-based robots, which are simultaneously recharging, which then pass on data collected to satellites for relaying back to data centers and customers.
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In these waning days of the second decade of the twenty-first century, technologists and investors are beginning to lay the foundations for new, truly transformational technologies that have the potential to reshape entire industries and rewrite the rules of human understanding.
It may sound lofty, but new achievements from businesses and research institutions in areas like machine learning, quantum computing and genetic engineering mean that the futures imagined in science fiction are simply becoming science.
And among the technologies that could potentially have the biggest effect on the way we live, nothing looms larger than genetic engineering.
Investors and entrepreneurs are deploying hundreds of millions of dollars to create the tools that researchers, scientists and industry will use to re-engineer the building blocks of life to perform different functions in agriculture, manufacturing and medicine.
One of these companies, 10X Genomics, which gives users hardware and software to determine the functionality of different genetic code, has already proven how lucrative this early market can be. The company, which had its initial public offering earlier this year, is now worth $6 billion.
Another, the still-private company Inscripta, is helmed by a former 10X Genomics executive. The Boulder, Colo.-based startup is commercializing a machine that can let researchers design and manufacture small quantities of new organisms. If 10X Genomics is giving scientists and businesses a better way to read and understand the genome, then Inscripta is giving those same users a new way to write their own genetic code and make their own organisms.
It’s a technology that investors are falling over themselves to finance. The company, which closed on $105 million in financing earlier in the year (through several tranches, which began in late 2018), has just raised another $125 million on the heels of launching its first commercial product. Investors in the round include new and previous investors like Paladin Capital Group, JS Capital Management, Oak HC/FT and Venrock.
“Biology has unlimited potential to positively change this world,” says Kevin Ness, the chief executive of Inscripta . “It’s one of the most important new technology forces that will be a major player in the global economy.”
Ness sees Inscripta as breaking down one of the biggest barriers to the commercialization of genetic engineering, which is access to the technology.
While genome centers and biology foundries can manufacture massive quantities of new biological material for industrial uses, it’s too costly and centralized for most researchers. “We can put the biofoundry capabilities into a box that can be pushed to a global researcher,” says Ness.
Earlier this year, the company announced that it was taking orders for its first bio-manufacturing product; the new capital is designed to pay for expanding its manufacturing capabilities.
That wasn’t the only barrier that Inscripta felt that it needed to break down. The company also developed a proprietary biochemistry for gene editing, hoping to avoid having to pay fees to one of the two laboratories that were engaged in a pitched legal battle over who owned the CRISPR technology (the Broad Institute and the University of California both had claims to the technology).
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Figuring out just what an AI is good at is one of the hardest thing about understanding them. To help determine this, OpenAI has designed a set of games that can help researchers tell whether their machine learning agent is actually learning basic skills or, what is equally likely, has figured out how to rig the system in its favor.
It’s one of those aspects of AI research that never fails to delight: the ways an agent will bend or break the rules in its endeavors to appear good at whatever the researchers are asking it to do. Cheating may be thinking outside the box, but it isn’t always welcome, and one way to check is to change the rules a bit and see if the system breaks down.
What the agent actually learned can be determined by seeing if those “skills” can be applied when it’s put into new circumstances where only some of its knowledge is relevant.
For instance, say you want to learn if an AI has learned to play a Mario-like game where it travels right and jumps over obstacles. You could switch things around so it has to walk left; you could change the order of the obstacles; or you could change the game entirely and have monsters appear that the AI has to shoot while it travels right instead.
If the agent has really learned something about playing a game like this, it should be able to pick up the modified versions of the game much quicker than something entirely new. This is called “generalizing” — applying existing knowledge to a new set of circumstances — and humans do it constantly.
OpenAI researchers have encountered this many times in their research, and in order to test generalizable AI knowledge at a basic level, they’ve designed a sort of AI arcade where an agent has to prove its mettle in a variety of games with varying overlap of gameplay concepts.

The 16 game environments they designed are similar to games we know and love, like Pac-Man, Super Mario Bros., Asteroids, and so on. The difference is the environments have been build from the ground up towards AI play, with simplified controls, rewards, and graphics.
Each taxes an AI’s abilities in a different way. For instance in one game there may be no penalty for sitting still and observing the game environment for a few seconds, while in others it may place the agent in danger. In some the AI must explore the environment, in others it may be focused on a single big boss spaceship. But they’re all made to be unmistakably different games, not unlike (though obviously a bit different from) what you might find available for an Atari or NES console.
Here’s the full list, as seen in the gif below from top to bottom, left to right:

You can imagine that an AI might be created that excels at the grid-based ones like Heist, Maze, and Chaser, but loses the track in Jumper, Coinrun, and Bossfight. Just like a human — because there are different skills involved in each. But there are shared ones as well: understanding that the player character and moving objects may have consequences, or that certain areas of the play area are inaccessible. An AI that can generalize and adapt quickly will learn to dominate all these games in a shorter time than one that doesn’t generalize well.
The set of games and methods for observing and rating agent performance in them is called the ProcGen benchmark, since the environments and enemy placements in the games are procedurally generated. You can read more about them, or learn to build your own little AI arcade, at the project’s GitHub page.
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U.K.-based lunar rover startup Spacebit, a company developing robotic exploration hardware for use on the Moon, announced two new partners that will help it develop and finalize its technology ahead of its target mission date of 2021. The Ecuadorian Civilian Space Agency (EXA) and Mexico’s Dereum will be providing the technology that Spacebit will employ on both its deployer and the robot rover it’s preparing for use on the Moon.
This marks the first time that Latin American companies will participate in a mission to the lunar surface, and Spacebit CEO Pavlo Tanasyuk was joined by Dereum CEO Carlos Mariscal and EXA COO Ronnie Nader to talk about the news at the International Astronautical Congress in Washington, D.C.
“We have Ecuador and Mexico as our technical partners,” Tanasyuk said. “So in addition to this being the first lunar mission from the U.K., it also is the first Latin American mission with a consortium of Latin American countries participating along with the U.K.”
Both the EXA and Dereum have strong technical chops when it comes to spacecraft and space-based robotics, with the EXA focusing on developing technology that is “efficient, cheap and reliable,” according to Nader, while Dereum’s Mariscal said that his organization is well-known globally for its work on building robots for use in space, with an extensive track record. Their expertise should help a lot in Spacebit’s efforts to build, test and validate its robotic lunar rover, which employs a novel walking system for getting around, whereas all rovers to date have used wheels for transportation.
“We are planning on doing a swarm technology exploration plan, where we have multiple small spider walking rovers deployed from a wheeled mothership, along with being able to have some redundancy and the ability to do 3D lidar scanning of the interior lunar caves and lava tubes,” Tanasyuk said.
“It’s essentially a data as a service business model,” he added, explaining how they’ll seek to monetize the business. “Our primary focus for early missions are to do exploration and mapping of lunar lava tubes to be able to characterize the lunar subsurface environment for potential suitability for future human habitation.”
Spacebit, founded in 2014, is funded privately via Tanasyuk himself, along with a couple of other private investors. He said that his company is fully funded through its first mission, a berth aboard the Peregrine Moon lander being launched by Astrobotic in 2021 (which itself has a price tag of $1.7 million he said). The first mission won’t be an entire swarm, but a single rover sent up as a demonstration unit to prove out its technology.
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LabGenius, a London-based startup applying AI and “robotic automation” to protein drug discovery, has raised $10 million in Series A funding.
The round is led by Lux Capital and Obvious Ventures, with participation from Felicis Ventures, Inovia Capital, Air Street Capital and existing investors. Also investing is Recursion Pharmaceuticals’ founder and CEO Chris Gibson, as well as Inovia Capital General Partner Patrick Pichette, who was formerly Google’s CFO.
Lux Capital’s Zavain Dar and Obvious Ventures’ Nan Li will join the LabGenius board of directors. Notably, the U.K. company’s early investors include Nathan Benaich, Torsten Reil, EF’s Matt Clifford, and Philipp Moehring, to name just a few.
“LabGenius is a full-stack protein engineering company: we combine artificial intelligence (AI), robotic automation and synthetic biology to evolve next-generation protein therapeutics,” founder and CEO Dr. James Field tells me.
“My central thesis, the thing that’s really the driving force behind the company, is the conviction that we’re entering an age in which humans will no longer be the sole agents of innovation. Instead, new knowledge, technologies and sophisticated real-world products will be invented by smart robotic platforms called empirical computation engines. An empirical computation engine is an artificial system capable of recursively and intelligently searching a solution space.”
LabGenius’ flagship technology is called “EVA,” which Field describes as a “machine learning-driven, robotic platform” capable of evolving new proteins. “As a smart robotic platform, EVA is capable of designing, conducting and critically learning from its own experiments,” he says.
The goal: to discover and develop new protein therapeutics that are currently hard for humans alone to find.

“For decades, scientists, engineers and technologists have dreamt of building ‘robot scientists’ capable of autonomously discovering new knowledge, technologies and sophisticated real-world products,” explains Field.
“For protein engineers, that dream has now entered the realm of possibility. The rapid pace of technological development across the fields of synthetic biology, robotic automation and ML has given us access to all the essential ingredients required to create a smart robotic platform capable of intelligently discovering novel therapeutic proteins.”
To that end, Field frames the development of EVA as a “long-term, ambitious undertaking” that he says will enable the startup to address previously unsolvable protein engineering challenges and in doing so, develop urgently needed therapeutics.
“My ultimate goal for LabGenius is to establish a fully integrated biopharmaceutical company powered by the world’s most advanced protein engineering platform,” he adds. “Quite honestly, this is a gargantuan undertaking and, while we’ve already established one of the world’s most technically sophisticated protein engineering operations, we’re only just scratching the surface of what’s possible.”
More broadly, there is a tension that many deep tech companies face, which is determining how best to develop technology that’s tightly aligned to real-world commercial needs (before running out of capital!). “For LabGenius, we’ve achieved this in a highly intentional way by undertaking a series of commercial projects of increasing complexity from the company’s earliest days,” Field says.
One on-going project is with Tillotts Pharma AG to identify and develop new drug candidates for the treatment of inflammatory bowel disease (IBD).
“Our business model is pretty simple,” says the LabGenius founder. “We use EVA to discover and characterise new drug molecules and then partner with pharma companies who can take these molecules to market. For example in a typical partner-financed early discovery program, we’ll take a project from concept to early pre-clinical stage. Typical deal structures include a blend of R&D payments, milestones & royalties.”
Meanwhile, LabGenius will use the capital to scale its team, expand the scope of its discovery platform and initiate an “internal asset development program.” The next goal is to evolve novel antibody fragments capable of treating conditions that cannot be addressed using conventional antibody formats.
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In our oceans the scale of disasters is measured in millions, billions, and trillions, while solutions amount to single digits: individuals or institutions working to impact a chosen issue with approaches often both brilliant and quixotic. Putting such individuals in close contact with both whales and billionaires is the strange alchemy being attempted by the Sustainable Ocean Alliance’s Accelerator at Sea.
I and a few other reporters were invited to observe said program, a five-day excursion in Alaska that put recent college graduates, aspiring entrepreneurs, legends of the sea, and soft-spoken financial titans on the same footing: spotting whales from Zodiacs in the morning, learning from one another in the afternoon, and drinking whiskey good and bad under the Northern lights in the pre-dawn dark.
The boat — no, not that big one, or that other big one… yes, that one.
In that time I got to know the dozen or so companies in the accelerator, the second batch from the SOA but the first to experience this oddly effective enterprise. And I also gathered from conversations among the group the many challenges facing conservation-focused startups.
(By way of disclosure, I should say that I was among four press offered a spot on the chartered boat; Those invited, from penniless students to deep-pocketed investors, could join provided they got themselves to Juneau for embarkation.)
The picture painted by just about everyone was one of impending doom from a multiplicity of interlinked trends, and as many different approaches to averting or mitigating that doom as people discussing it.
In Silicon Valley one grows so used to seeing enormous sums of money expended on things barely categorizable as irritations, let alone serious problems, that it is a bit bewildering to be presented with the opposite: existential problems being addressed on shoestring budgets by founders actually passionate about their domain.
Throughout the trip, the discussions had at almost every occasion, be it looking for bear prints in a tidal flat or visiting a local salmon hatchery, were about the imminent collapse of natural ecosystems and the far-reaching consequences thereof.
Overfishing, rising water temperatures, deforestation, pollution, strip mining, microplastics — everywhere we looked is a man-made threat that has been allowed to go too far. Not a single industry or species is unaffected.
It’s enough to make you want to throw your hands up and go home, which is in fact what some have advised. But the people on this boat are not them. They were selected for their dedication to conservation and ingenuity in pursuing solutions.
Of course, there’s no “solution” to the million of tons of plastic and oil in the oceans poisoning fish and creating enormous dead zones. There’s no “solution” to climate change. No one expects or promises a miracle cure for nature’s centuries of abuse at human hands.
But there are mitigations, choices we can make and technologies we can opt for where a small change can propagate meaningfully and, if not undo the damage we’ve done, reduce it going forward and make people aware of the difference they can make.
The trip came right at the beginning of the accelerator, a choice that meant they were only getting started in the program and in fact had never met one another. It also meant in many cases their pitches and business models were less than polished. This is for the most part an early-stage program, and early in the program at that.
That said, the companies may be young but the ideas and technologies are sound. I expect to follow up with many as they perfect their hardware, raise money, and complete pilot projects, but I think it’s important to highlight each one of them, if only briefly. The accelerator’s demo day is actually today, and I wish I could attend to see how the companies and founders have evolved.
Some accelerators are so big and so general-purpose that it was refreshing to have a manageable number of companies all clustered around interlinked issues and united by a common concern. If young entrepreneurs trying to change the world isn’t TechCrunch business, I don’t know what is.
The problems may be multifarious, but I managed to group the startups under two general umbrellas: waste reduction and aquatic intelligence.
But before that I want to mention one that doesn’t fit into either category and for other reasons deserves a shout out.
Coral Vita is working on a special method of fast-tracking coral growth and simultaneously selecting for organisms resistant to bleaching and other threats. The founder, Gator Halpern, impressed the importance of the coral systems on us over the trip, as did filmmaker Jeff Orlowski, who directed the harrowing documentaries Chasing Ice and Chasing Coral. (He gave a workshop on storytelling — important when you’re pitching a film or a startup.)
Gator is using a special method to grow corals at 50 times normal rates and hopefully resuscitate reefs around the world, which is awesome, but I wanted to put Coral Vita first because of a horribly apropos coincidence: Hurricane Dorian, the latest in a historically long unbroken line of storms, struck his home and lab in the Bahamas while we were at sea.
It was literally battering the islands while he was supposed to pitch investors, and he used his time instead to ask us to help the victims of the storm. That’s heart. And it serves as a reminder that these are not armchair solutions to invented problems.
If you can spare a buck, you can support Coral Vita and victims of Dorian in the Bahamas here.
The other companies were addressing problems equally as destructive, if not quite so immediately so.
Humans produce a lot of waste, and a lot of that waste ends up in the ocean, either as whole plastic bags scooping up fish, microplastics poisoning them, or heavier trash cluttering the sea floor. These startups focused on reducing humanity’s deleterious effects on ocean ecosystems.
Cruz Foam is looking to replace one of my least favorite substances, Styrofoam, which I see broken up and mixed in with beach soil and sand all the time. The company has created a process that uses an incredibly abundant and strong material called chitin to create a lightweight, biodegradable packing foam. Chitin is what a lot of invertebrates use to form their shells and exoskeletons, and there’s tons of it out there — but the company has been careful to find ethical sourcing for the volume it need.
Cruz Foam’s chitin-based product, left, and Biocellection’s plastic reduction process.
Biocellection is coming from the other direction, having created a process to break down polyethylenes (i.e. plastics) into smaller molecules that are useful in existing chemical processes. It’s actually upcycling waste plastic rather than repurposing it as a lower grade product.
Loliware was in SOA’s first batch, and creates single-use straws out of kelp material — a timely endeavor, as evidenced by the $6M round A they just pulled in, and backlog of millions of units ordered. Their challenge now is not finding a market but supplying it.
Dispatch Goods and Muuse are taking complementary approaches to reducing single-use items for take-out. Dispatch follows a model in use elsewhere in the world where durable containers are used rather than disposable ones for delivery items, then picked up, washed, and reused. Kind of obvious when you think about it, which is it’s common in other places.
Muuse (formerly Revolv) takes a more tech-centric approach, partnering with coffee shops to issue reusable cups rather than disposable ones. You can keep the cup if you want, or drop it off at a smart collection point and get a refund; RFID tags keep track of the items. Founder Forrest Carroll talked about early successes with this model on semi-closed environments like airports and college campuses.

Repurpose is aiming to create a way to go “plastic neutral” the way people try to go “carbon neutral.” Companies and individuals can sponsor individual landfills where their plastics go, subsidizing the direct removal and handling costs of a given quantity of trash.
Finless Foods hopes to indirectly reduce the huge amount of cost and waste created by fishing (“sustainable” really isn’t) by creating lab-grown tuna tissue that’s indistinguishable from the real thing. It’s a work in progress, but they’ve got a ton of money so you can probably count on it.
The technology used in the maritime and fishing industries tends toward the “sturdy legacy” type rather than “cutting edge.” That’s changing as costs drop and the benefits of things like autonomous vehicles and IoT become evident.
Ellipsis represents perhaps the most advanced, yet direct, application of the latest tech. The company uses camera-equipped drones using computer vision to inspect rivers and bodies of water for plastics, helping cleanup and response crews characterize and prioritize them. This kind of low-level data is largely missing from cleanup efforts, which gave rise to the name, which refers to both the peripatetic founder Ellie and the symbol indicating missing or omitted information
Ellipsis uses computer vision to find plastic waste in water systems.
For larger-scale inspection, autonomous boats like Saildrone are an increasingly valuable tool — but they cost hundreds of thousands of dollars and have their own limitations.
EcoDrone is a lower-cost, smaller, customizable autonomous sailboat that costs more like $2,500. Plenty of missions would prefer to deploy a fleet of smaller, cheaper boats than put all their hopes into one vessel.

Sea Proven is going the other direction, with a much larger autonomous ship: 20 meters long with a full ton of payload space. That opens up entirely new mission profiles that use sophisticated, large-scale equipment and require long-term presence at sea. The company has two ships now embarking on a mission to track whales in the Mediterranean.
Nets and traps are notoriously dumb, producing a huge amount of “bycatch,” animals caught up in them that aren’t what the fishing vessel was aiming (or licensed) to collect. Smart Catch equips these huge nets with a camera that tracks and characterizes the fish that enter, allowing the owner to watch and monitor them remotely and respond if necessary.

Meanwhile “dumb” traps can still be smarter in other ways. Stationary traps in stormy seas are often lost, dragged along the sea bed to an unknown location, there to sit attracting hapless crab and fish until they fall apart centuries from now. Blue Ocean Gear makes GPS-equipped buoys that can be tracked easily, reducing the risk of losing expensive fishing kit and line, and preventing “ghost fishing.”
Connectivity at sea can be problematic, with satellite often the only real option. Sure, Starlink and others are on their way, but why wait? A system of interconnected floating hubs from ONet could serve as hotspots for ships carrying valuable and voluminous data that would otherwise need to be processed at sea or uploaded at great cost.

And integrating all that data with other datasets like those provided by universities, ports, municipalities, NGOs… good luck getting it all in one place. But that’s the goal of SINAY, which is assembling a huge ocean-centric meta-database where users can cross-reference without having to sort or process it locally. Clouds come from oceans, right? So why shouldn’t the ocean be in the cloud?
The idea of commencing this accelerator program with a trip to southeast Alaska is a fanciful one, no doubt. But an influx of support for the accelerator’s parent organization, the Sustainable Ocean Alliance, made it possible. The SOA raised millions from the mysterious Pine and not-so-mysterious Benioffs, but it also made a deep impression on the founder of Lindblad Expeditions, Sven Lindblad, who offered not just to host the event but to attend and speak at it.
He joined several other experts and interesting people in doing so: Former head of Google X Tom Chi, Value Act’s Jeff Ubben, Gigi Brisson and her Ocean Elders, including Captain (ret.) Don Walsh, the first man to reach the bottom of the Challenger Depths in the Marianas Trench. He’s hilarious, by the way.
I met SOA founder Daniela Fernandez at a TechCrunch event a few years ago when all this was just one of many twinkles in her twinkly eyes, and it’s been rewarding to watch her grow a community around these issues, which have passionate supporters around the globe if you’re willing to look for them and validate their purpose. It’s not a surprise to me at all that she has collected such an impressive group.
The boat, departing from Juneau, made a number of stops at local places of interest, where we would meet locals in the fishing industry, whale researchers, and others, or hear about the local economy ecology from one of the boat’s designated naturalists. In between these expeditions we did team-building exercises, honed pitches, and heard talks from the people mentioned above on hiring practices, investment trends, history.
These people weren’t just plucked from from the void — they are all part of the extended community that the SOA and Fernandez have built over the last few years. The organization was built with the idea of putting young, motivated people together with older, more experienced ones, and that’s just what was happening.

In a way it was what you might expect out of an accelerator program: Connecting startups with industry veterans and investors (of which there were several present) and getting them the advice and exposure they need. There was a pitch competition — the “Otter Sanctuary” (you had to be there).
But there was something very different about doing it this way — on a boat, I mean. In Alaska. With bears, whales, and the northern lights present at every turn.
“For the first time ever, we brought together a community of ocean entrepreneurs from all around the world and allowed them to become fully immersed in the environment that they have been working so hard to protect,” said Craig Dudenhoffer, who runs the accelerator program. “It was amazing to see the entrepreneurs establishing lifelong relationships with each other and with members of the SOA community. It might seem counter-intuitive for a technology entrepreneur, but sometimes you have to disconnect from technology in order to reconnect with your mission.”
In a normal startup accelerator, and in fact for the remainder of this one, aspiring entrepreneurs are living on their own somewhere, coming into a shared office space, attending office hours, meeting VCs in their offices or at demo days. That’s just fine, and indeed what many a startup needs — a peer group, a focal point in space and time, goals and advice.
On the boat, however, these things were present, but secondary to the experience of, say, standing next to someone under the aurora. I’m aware of how that sounds — “it was an experience, man!” — but there’s something fundamentally different about it.
In an office in the Bay Area, there is an established power structure and hierarchy. Schedules are adjusted around meetings, priorities are split, time and attention are devoted in formal 15-minute increments. On the boat there was no hierarchy, or rather the artificial one to which we would cleave in the city was flattened by the scale of what we were learning and experiencing.

You’d be in a zodiac or pressed against the railing with your binoculars, talking about whales and the threat of microplastics with whoever’s next to you in a normal fashion, only to find out they’re a billionaire who you’d never be able to meet directly with at all, let alone on equal terms.
Sitting at breakfast one day the guy next to me started talking about hydrogen-powered trucking — I figured I’d indulge this harmless idealist. In fact it was Jeff Ubben and Value Act was investing millions in an ecosystem they fully expect to take over the west coast. This sort of encounter was happening constantly as people engaged naturally, acting outside the established hierarchies and power structures.
Part of that was the gravity of the issues the startups were facing, and which we were reminded of repeatedly by the impending hurricane, the hatchery warning of salmon apocalypse, the visibly collapsing ecosystems, and perhaps most poignantly by the changes seen personally by Don and Sven, who were been on the seas professionally long before I was even born.
On the last night of the trip, I shared a glass of wine with Sven to talk about why he was supporting this endeavor, which was undoubtedly expensive and certainly unusual.
“From a business perspective, I depend on the ocean — but there’s a personal connection as well. I’m constantly looking for ways to protect what we depend on,” he began. “We have a fund that generates a couple million dollars a year, and we find different people that we believe in — that have an idea, a passion, intelligence. You meet someone like Daniela, you want to go to bat for them.”

“When you’re 21 or whatever, you have all these idealistic thoughts about making a difference in the world. They need support in a variety of ways — advice, finance, mentorship, all these things are part of the puzzle,” he said. “What SOA has done is recognize people that have a good idea. Left to their own devices most of them would probably fail. But we can provide some support, and it’s like with salmon eggs – maybe instead of one in a million surviving, maybe two, or five survive, you know?”
“Tech is a valuable tool, but it has to serve to support an idea. It isn’t the idea. Eliminating plastics and bycatch, making data more useful, putting sonar sensors on robotic boats, all very interesting. We need solutions, actions, ideas, as fast as we can, to accelerate the change in behavior as fast as we can.”
His earnest replies soon became emotional, however, as his core concern for the ocean and planet in general took over.
“We’re fucked,” he said simply. “We are literally destroying the next generation’s future. I’ve been with colleagues and we’ve wept over glasses of wine over what we’re doing.”
“I have two personalities,” he explained. “And most of my friends, associates, scientists have these dual personalities, too. One is when they look in the mirror and talk to themselves — that tends to be more pessimistic. But the other is the external personality, where being pessimistic is not helpful.”
“Something like this really activates that optimism,” he said. “At the end of the day young people have to grab their future, because we sure haven’t done a great job of it. They have to get out there, they have to vote, they have to take control. Because if the system really starts to collapse… I don’t think anyone even begins to understand the magnitude of it. It’s unfathomable.”
The Accelerator at Sea program was a fascinating experience and I’m glad to have taken part. I feel sure it was valuable for the startups as well, and not just because of the $25,000 they were each spontaneously awarded from the investors on board, who in closing remarks emphasized how important it is that startups like these and the people behind them are supported by gatekeepers like venture firms and press.
The combination of good times in nature, stimulating experts and talks, and a group of highly motivated young entrepreneurs was a powerful mixture, and unfortunately one that is difficult to describe even in 3,000 words. But I’m glad it exists and I look forward to following the progress of these companies and the people behind them. You can keep up with the SOA at its website.
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The number of objects in orbit around Earth has been growing, and growing fast. Before 1957, of course, there were a total of zero human-made objects in the orbital region of outer space just beyond Earth’s atmosphere. There were 4,987 satellites orbiting the globe at the start of this year, according to the U.N. Office for Outer Space Affairs, which is up nearly three percent from the year before. 2017 was a record year for orbital object launches, but with ambitious new satellite constellations planned by SpaceX and others, that’s a record that’s likely to be beat in relatively short order.
Nor are all of those satellites equipped with modern technology: All told, 8,378 objects have been launched to orbit according to the UNOOSA records, and a sizeable percentage of those spacecraft are more than a few years old.
In fact, earlier this month, Bigelow Airspace was informed by the U.S. Air Force that there’s a 5.6 percent chance that one of its satellites could collide with a Russian ‘zombie’ satellite no longer in operation, and one of Starlink’s satellites had a near-miss with one operated by the European Space Agency.
A new industry organization called the Space Safety Coalition has just issued guidelines outlining best practices for companies operating spacecraft in low-Earth orbit, with signees including Immarsat, Iridium, Planet, Rocket Lab, Virgin Orbit and more.
I spoke with Walter Scott, the Chief Technical Officer of publically-traded space tech company Maxar Technologies, about the new initiative, in which longtime space operator Maxar is a founding member, and why now is the right time for the satellite industry to self-regulate when it comes to sharing low-Earth orbital space.
“The best time to solve a problem is before it’s a crisis, even though that doesn’t seem to be normal human behavior,” he told me.
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During a press conference held just after 6 AM JST, Mitsubishi Heavy Industries Launch Director Atsutoshi Tamura and the Director of JAXA’s Tanegashima Space Center Takeshi Fujita detailed what the two partners knew so far about the cause of their aborted HTV-8 mission on Tuesday.
The launch, scheduled to take place at 6:33 AM JST, instead was officially scrubbed at around 4:34 AM JST due to a fire on the mobile launcher upon which the Mitsubishi Heavy Industries H-IIB rocket was sitting ready for launch. The fire began at 3:05 AM JST according to Tamura, and efforts began immediately to extinguish it immediately, with the fire finally being completely put out (as far as JAXA and MHI can tell) by 5:10 AM JST.
So far, all that is known about the fire is that it occurred in a small hole in the platform located between the third and fourth solid propellant boosters, which is designed to provide a venting channel for fire put out by the rocket’s engines when it’s operating normally during launch. This aperture is made of metal, and surrounded by fire retardant materials, which makes it very unlikely for it to catch fire normally. Both Tamura and Fujita confirmed that this specific situation has not happened previously with any prior launches.
The actual cause of the fire remains unknown, and so far, JAXA and MHI staff have not been able to approach the launch vehicle for a closer inspection due to safety considerations. They are confident based on observation from a distance that they’ve succeeded in putting the fire out, and anticipate being able to approach the rocket later today to perform an in-person inspection.
The vehicle was fully fueled when the fire began, but the fuel was quickly siphoned out when the fire was discovered. It’s not yet clear what damage to the launch vehicle has resulted from the incident. The cargo, which included a significant amount of supplies for ISS astronauts, doesn’t initially appear to have been damaged but further inspection will be required, per MHI and JAXA. There isn’t an urgent need for those supplies, however, JAXA confirms.
At the very earliest, the next launch attempt will be September 17, MHI shared, but this date is highly dependent on the results of the investigation into the cause of the fire.
The original article, including updates, follows below.
[Update 09/11/19 4:34 AM JST: JAXA and MHI confirm the launch is scrubbed for today. We’ll find out more at a press conference at 6 AM JST, including whether there is any chance of making an attempt in the backup window.]
[Update 09/11/19 4:07 AM JST: JAXA and MHI confirm that there is a fire on the Mobile Launcher upon which the H-IIB is loaded to roll out to the launch pad. The fire, described as ‘small,’ started at 3:10 AM JST and continues as of this writing at 4:07 AM JST, while attempts are underway to extinguish it, as you can see in the photo captured on site by TechCrunch below. We’ll provide more updates as they become available.]
Mitsubishi Heavy Industries’s Launch Services division is all set to send a crucial cargo payload to the International Space Station from JAXA today. The launch is scheduled for 6:33 AM Japan Standard Time (5:33 PM ET/2:33 PM PT), and will take off from Tanegashima Island, at JAXA’s Tanegashima Space Center.
The rocket used for this launch is the Mitsubishi Heavy Industries (MHI) H-IIB, and this is the eighth flight launch of the H-II Transfer Vehicle (HTV) that MHI designed and built in Japan.
In the H-IIB configuration, the MHI-built rocket that will transport he HTV includes a liquid propellant central core, along with four solid propellant rocket boosters to give it additional life capacity. This particular mission will see the HTV loaded with 5.3 metric tons (just under six U.S. tons) of supplies for the ISS on board in both pressurized and unpressurized cargo containers, which divvy up the total capacity.
One of the crucial pieces of cargo going up is a small satellite deployment device, called “Kibo,” created by the Kyushu Institute of Technology and the National Authority for Remote Sensing and Space Science. It’ll be used to deploy a range of super compact CubeSats also on board, including a propulsion tech demo created by the University of Tokyo and startup Space BD, which is the first company awarded a contract by JAXA to be the commercial operator for deploying smallsats from the ISS via Kibo.
NASA TV will be carrying the launch live via the stream above, with their coverage kicking off around 5 PM ET (2 PM PT/6 AM JST).
Disclosure: MHI covered the travel costs associated with this launch.
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