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In an increasingly hot biotech market, protecting IP is key

After a record year for biotech investment in 2020 — during which the industry saw $28.5 billion invested across 1,073 deals — the market for new innovations remains strong. What’s more, these innovations are increasingly coming to market by way of early-stage startups and/or their scientific founders from academia.

In 2018, for instance, U.S. campuses conducted $79 billion worth of sponsored research, much of it thanks to the federal government. That number spiked amid the pandemic and could increase even more if President Biden’s infrastructure plan, which includes $180 billion to enhance R&D efforts, passes.

Since 1996, 14,000 startups have licensed technology out of those universities, and 67% of licenses were taken by startups or small companies. Meanwhile, the median step-up from seed to Series A is now 2x — higher than all other stages, suggesting that biotech startups are continuing to attract investment at earlier stages.

When it comes to protecting IP, early and consistent communication with investors, tech transfer offices and advisers can make all the difference.

For biotech startups and their founders, these headwinds signal immense promise. But initial funding is only one part of a long journey that (ideally) ends with bringing a product to market. Along the way, founders will need to procure additional investments, develop strategic partnerships and stave off competition. All of which starts by protecting the fundamental asset of any biotech company: its intellectual property.

Here are three key considerations for startups and founders as they get started.

Start with an option agreement

Most early-stage biotechnology starts in a university lab. Then, a disclosure is made with the university’s tech transfer office and a patent is filed with the hopes that the product can be taken out into the market (by, for instance, a new startup). More often than not, the vehicle to do this is a licensing agreement.

A licensing agreement is important because it shows investors the company has exclusive access to the technology in question. This in turn allows them to attract the investments required to truly grow the company: hire a team, build strategic partnerships and conduct additional studies.

But that doesn’t mean jumping right to a full-blown licensing agreement is the best way to start. An option agreement is often the better move.

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What the growing federal focus on ESG means for private markets

The increasing regulation of ESG (environmental, social, governance) disclosure reporting may have started in the public markets, but will almost certainly have downstream effects for private market actors — for founders, companies and investors.

Since his confirmation as the chair of the U.S. Securities and Exchange Commission in April, Gary Gensler has made reforming ESG disclosures concerning climate change risk and human capital a top priority. The SEC’s regulatory agenda confirms as much. And Gensler is not alone in his focus on ESG at the federal level.

President Joe Biden issued an executive order encouraging regulators to assess climate-related financial risk. At the end of March, Treasury Secretary Janet Yellen wrote on Twitter that “our future livelihoods … depend on the financial sector to build a more sustainable and resilient economy.” Congress is considering measures that would require increased ESG disclosures, including the Improving Corporate Governance Through Diversity Act, the Diversity and Inclusion Data Accountability and Transparency Act and the Climate Risk Disclosure Act.

This renewed federal focus on ESG issues will bolster the SEC’s effort to create disclosure practices for public companies and mutual funds. Regardless of whether these federal policies around ESG come to pass, they reflect a momentum that will almost certainly impact private markets:

  • Firms that want to go public — whether via SPAC, direct listing or traditional IPO — may have to seriously consider board diversity or environmental reporting in conjunction with — or well in advance of — their debuts.
  • Private companies seeking to align with public companies as vendors or partners may be expected to meet specific ESG requirements before the engagement.
  • Startup founders and venture funds raising capital may work to maintain the largest target market by proactively scoping ESG engagements to ensure they meet criteria for investors who may have their own ESG-focused investment requirements.

In his confirmation hearing before the Senate in early March, Gensler said, “Markets — and technology — are always changing. Our rules have to change along with them.”

The federal government is moving to increase regulation around ESG disclosure requirements with the goals of establishing greater transparency and metrics for public companies.

The federal government is moving to increase regulation around ESG disclosure requirements with the goals of establishing greater transparency and metrics for public companies. These requirements are a response to the changing markets — demands from consumers, scrutiny from investors and a general insistence for higher corporate standards from society at large.

Private markets aren’t immune to these forces. Already, three-quarters of investors in a 2020 survey said it was very important to measure the success of sustainability initiatives, but they also said there’s been a lack of clarity on how to define and measure outcomes.

To be sure, private markets are not headed toward full-scale adoption of ESG regulations. They will not be subject to the same reporting or disclosures framework as their public counterparts. Not today, and possibly not for some time.

But we may begin to see private investors, funds and companies adapting to get ahead of ESG regulation and position themselves to effectively operate in a new — albeit adjacent — regulatory environment. In their case, the rules may not change — but the game could.

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Extra Crunch roundup: Crucial API metrics, US startup funding, advanced SEO tactics

On a recent episode of Extra Crunch Live, Retail Zipline founder Melissa Wong and Emergence Capital investor Lotti Siniscalco joined Managing Editor Jordan Crook to walk attendees through Zipline’s Series A deck.

Interestingly, the conversation revealed that Wong declined an invitation to do a virtual pitch and insisted on an in-person meeting.

“She was one of the few or maybe the only CEO who ever stood up to pitch the entire team,” said Siniscalco.

“She pointed to the screen projected behind her to help us stay on the most relevant piece of information. The way she did it really made us stay with her. Like, we couldn’t break eye contact.”


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Beyond Wong’s pitch technique, this post also examines some of the key “customer love” metrics that helped Zipline win the day, such as CAC, churn rates and net promoter score.

“In retrospect, I really underestimated the competitive advantage of coming from the industry,” said Wong. “But it resulted in the numbers in our deck, because I know what customers want, what they want to buy next, how to keep them happy and I was able to be way more capital-efficient.”

Read our recap with highlights from their conversation, or click though to watch a video with their entire chat.

Thanks very much for reading Extra Crunch this week!

Walter Thompson
Senior Editor, TechCrunch
@yourprotagonist

Investors don’t expect the US startup funding market to slow down

Global venture capital reached $156 billion in Q2 2021, a YOY increase of 157%. A record number of unicorns found their feet during the same period and valuations rose across the board, report Anna Heim and Alex Wilhelm in today’s edition of The Exchange.

Even if round counts didn’t set all-time highs, “the general vibe of Q2 venture capital data was clear: It’s a great time for startups looking to raise capital.”

Anna and Alex are interviewing VCs in different regions to find out why they’re feeling so generous and optimistic. Today, they started with the following U.S.-based investors:

  • Amy Cheetham, principal, Costanoa Ventures
  • Marlon Nichols, founding managing partner, MaC Venture Capital
  • Vanessa Larco, partner, New Enterprise Associates
  • Jeff Grabow, venture capital leader, EY US

Despite the hype, construction tech will be hard to disrupt

Image of two construction workers examining blueprints next to a laptop to represent tech on construction sites.

Image Credits: AzmanJaka (opens in a new window) / Getty Images

The construction industry might seem like a sector wanting innovation, Safe Site Check In CEO and founder David Ward writes in a guest column, but there are unique challenges that make construction firms slow to adapt to new technology.

From the way construction projects are funded to complicated local regulations, there’s no one-size-fits-all solution for the construction industry’s tech problems.

Construction tech might be appealing to investors, Ward writes, but it must be “easy to use, easy to deploy or access while on a job site, and improve productivity almost immediately.”

 

3 analysts weigh in: What are Andy Jassy’s top priorities as Amazon’s new CEO?

Jeff Bezos, executive chairman and Andy Jassy, CEO at Amazon

Image Credits: AP Photo/Isaac Brekken/John Locher

Now that he’s stepping away from AWS and taking over for Jeff Bezos, what are the biggest challenges facing incoming Amazon CEO Andy Jassy?

Enterprise reporter Ron Miller reached out to three analysts to get their take:

  • Robin Ody, Canalys
  • Sucharita Kodali, Forrester
  • Ed Anderson, Gartner

Amazon is listed second in the Fortune 500, but it’s not all sunshine and roses — maintaining growth, unionization, and the potential for antitrust regulation at home and abroad are just a few of his responsibilities.

“I think the biggest to-do is to just continue that momentum that the company has had for the last several years,” Kodali says. “He has to make sure that they don’t lose that. If he does that, I mean, he will win.”

The most important API metric is time to first call

Close up of a stopwatch resting on a laptop's trackpad.

Image Credits: Peter Dazeley (opens in a new window) / Getty Images

Publishing an API isn’t enough for any startup: Once it’s released, the hard work of cultivating a developer base begins.

Postman’s head of developer relations, Joyce Lin, wrote a guest post for Extra Crunch based on the findings of a study aimed at increasing adoption of APIs that utilize a public workspace.

Lin found that the most important metric for a public API is time to first call (TTFC). It makes sense — faster TTFC allows developers to begin using new tools quickly. As a result, “legitimately streamlining TTFC results in a larger market potential of better-educated users for the later stages of your developer journey,” writes Lin.

This post isn’t just for the developers in our audience: TTFC is a metric that product and growth teams should also keep top of mind, they suggest.

“Even if your market is defined as a limited subset of the developer community, any enhancements you make to TTFC equate to a larger available market.”

 

Q3 IPO cycle starts strong with Couchbase pricing and Kaltura relisting

Image Credits: olli0815/iStock

Couchbase and Kaltura offered new filings Monday, with NoSQL provider Couchbase setting an initial price range for its IPO and Kaltura resurrecting its public offering with a fresh price range and new financial information.

“Both bits of news should help us get a handle on how the Q3 2021 IPO cycle is shaping up at the start,” Alex Wilhelm writes.

 

5 advanced-ish SEO tactics to win in 2021

SEO tactics for the underdog

Image Credits: PM Images (opens in a new window)/ Getty Images

Mark Spera, the head of growth marketing at Minted, offers SEO tips to help smaller sites stand out.

He writes in a guest column that Google’s algorithm “errs on the side of caution,” which leads the search engine to favor larger, more established websites.

“The cards aren’t in your favor, so you need to be even more strategic than the big guys,” he writes. “This means executing on some cutting-edge hacks to increase your SEO throughput and capitalize on some of the arbitrage still left in organic search. I call these five tactics ‘advanced-ish,’ because none of them are complicated, but all of them are supremely important for search marketers in 2021.”

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Q3 IPO cycle starts strong with Couchbase pricing and Kaltura relisting

Today we have new filings from Couchbase and Kaltura: Couchbase set an initial price range for its IPO, something we’ve been waiting for, and Kaltura’s offering is back from hiatus with a new price range and some fresh financial information to boot.

Both bits of news should help us get a handle on how the Q3 2021 IPO cycle is shaping up at the start.

TechCrunch has long expected the third quarter’s IPO haul to prove strong; investors said as 2020 closed that quarters one, three and four would prove very active in terms of public market exits this year. Then the second quarter surpassed expectations, with more companies going public than at least some market observers anticipated.

With that in mind, you can imagine why the newly launched Q3 could prove an active period.

So! Let’s start with a dig into the filing from NoSQL provider Couchbase, working to understand its first price range and what the numbers may say about market demand for technology debuts. Here’s our first look at the company’s value. Then we are taking the Kaltura saga back up, checking into the pricing and second-quarter results from the technology company that provides video-streaming software and services.

Frankly, I’ve been waiting for these filings to drop. So, let’s cut the chat and get into the numbers:

Couchbase’s IPO price range

In its new S-1/A filing, Couchbase reports that it anticipates a $20 to $23 per share IPO price. With a maximum sale of just over 8 million shares, Couchbase could raise as much as $185.15 million in its public offering.

The company will have 40,072,801 shares outstanding after its IPO, not including 1,050,000 shares that are reserved for possible release. The math from here is simple. To calculate Couchbase’s possible simple IPO valuation we can just do a little multiplication:

  • Couchbase simple valuation at $20 per share: ~$802 million.
  • Couchbase simple valuation at $23 per share: ~$922 million.

If you want to include the company’s reserved shares, add $21 million to the first figure, and $24.2 million to the second. Notably, TechCrunch wrote before it priced that using a historical analog from the Red Hat-IBM sale — both Couchbase and Red Hat work in the OSS space — the company would be worth around $900 million. So, we were pretty close.

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Edtech startup Microverse raises $12.5M to bring income share agreements to the developing world

Edtech startup Microverse has tapped new venture funding in its quest to help train students across the globe to code through its online school that requires zero upfront cost, instead relying on an income-share agreement that kicks in when students find a job.

The startup tells TechCrunch it has closed a $12.5 million Series A led by Northzone with additional participation from General Catalyst, All Iron Ventures and a host of angel investors. We last covered the company after it had closed a bout of seed funding from General Catalyst and Y Combinator; this latest round brings the startup’s total funding to just under $16 million.

The company’s vision has seen added pandemic-era traction as larger tech companies have embraced remote work that spans geographic boundaries and time zones. Microverse has now brought English-speaking students from over 188 countries through its program.

Since we last chatted, CEO Ariel Camus says the startup has landed some 300 early graduates in positions at tech companies including Microsoft, VMWare and Huawei. The company says its has above a 95% employment rate for its students within six months of graduation so far, pushing past one of the bigger issues that income-share-agreement-based schools have had stateside — getting graduates employed.

Microverse does have notably less generous terms than counterparts like Lambda School when it comes to when students begin loan repayment, the terms of both are actually quite different, as noted in my previous article:

While Lambda School’s ISA terms require students to pay 17% of their monthly salary for 24 months once they begin earning above $50,000 annually — up to a maximum of $30,000, Microverse requires that graduates pay 15% of their salary once they begin making more than just $1,000 per month, though there is no cap on time, so students continue payments until they have repaid $15,000 in full. In both startups’ cases, students only repay if they are employed in a field related to what they studied, but with Microverse, ISAs never expire, so if you ever enter a job adjacent to your area of study, you are on the hook for repayments. Lambda School’s ISA taps out after five years of deferred repayments.

The startup has made efforts to streamline their online program since launch to ensure that students are being set up to succeed in the full-time, 10-month program. Part of Microverse’s efforts have included condensing lesson segments into shorter time frames to ensure students aren’t starting the program unless they have enough free time to commit. Camus says the startup is receiving thousands of applications per month, of which only a fraction are accepted in an effort to ensure that the small startup isn’t overcommitting itself early on. The startup estimates it will usher 1,000 students through its program this year.

The startup has big plans for the future, including working more closely with tech companies to ensure that students have easier access to job placement once they graduate.

“We have data now that the day we launch a partner program — which we haven’t done yet but we will eventually — it opens up the market by 5x,” Camus tells TechCrunch. “To get 10,000 students per year in a world where 90% of the world’s population doesn’t have access to higher education — it’s not going to be that hard, to be honest, I’m not too worried.”

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Autonomous trucking startup Embark to go public in $5.2B SPAC deal

Five-year old self-driving truck startup Embark Trucks Inc. said Wednesday it would merge with special purpose acquisition company Northern Genesis Acquisition Corp. II in a deal valued at $5.2 billion.

Embark takes a different approach to autonomous trucking: As opposed to manufacturing and operating a fleet of trucks themselves, which is the route rival TuSimple is taking, Embark offers its AV software as a service. Carriers and fleets can pay a per-mile subscription fee to access it. The company includes carriers Mesilla Valley Transportation and Bison Transport, and companies Anheuser-Busch InBev and HP Inc., among its partners.

Carriers purchase trucks with compatible hardware directly from OEMs, so Embark says it has designed its system to be “platform agnostic” across multiple components and manufacturers. The company says its software can simulate up to 1,200, 60-second scenarios per second, and make adaptive predictions using those scenarios for the behavior of other vehicles on the road.

Embark said in an investor presentation for the SPAC deal that it was targeting “driver-out,” or operating on roads without a safety driver, by 2023 and launching at a commercial scale across the American sunbelt the following year. However, Embark still has technical milestones yet to achieve, noting in the presentation that the software still needs to accomplish actions, such as interactions with emergency vehicles and responding to blown tires and other mechanical failures.

Upon closing, the transaction will inject Embark with around $615 million in gross cash proceeds, including $200 million in private investment in public equity (PIPE) funding from investors, including CPP Investments, Knight-Swift Transportation, Mubadala Capital, Sequoia Capital and Tiger Global Management.

Embark also said former Department of Transportation Secretary Elaine Chao was joining its board, likely a boon for a company operating in the autonomous trucking industry, which is still only authorized for commercial deployment in 24 states.

Embark was founded in 2016 by CEO Alex Rodrigues and CTO Brandon Moak, who worked together on autonomous driving while completing engineering degrees from Canada’s University of Waterloo. After launching out of Y Combinator, the company quickly went on to raise $117 million in total funding, including a $30 million Series B led by Sequoia Capital and a $70 million Series C led by Tiger Global Management.

The transaction is anticipated to close in the second half of 2021. The company joins competitor AV trucking developer Plus in going public via a SPAC merger. TuSimple opted for a traditional initial public offering in March.

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Holy Grail raises $2.7M seed fund to create modular carbon capture devices

The founders of Holy Grail, a two-year-old startup based in Mountain View, California, are taking a micro approach to solving the outsized problem of capturing carbon.

The startup is prototyping a direct air carbon capture device that is modular and small — a departure from the dozens of projects in the U.S. and abroad that aim to capture CO2 from large, centralized emitters, like power plants or industrial facilities. Holy Grail co-founder Nuno Pereira told TechCrunch that this approach will reduce costs and eliminate the need for permits or project financing.

While Holy Grail has a long development and testing phase ahead, the idea has captured the attention and capital from well-known investors and Silicon Valley founders. Holy Grail recently raised $2.7 million in seed funding from LowerCarbon Capital, Goat Capital, Stripe founder Patrick Collison, Charlie Songhurst, Cruise co-founder Kyle Vogt, Songkick co-founder Ian Hogarth, Starlight Ventures and 35 Ventures. Existing investors Deep Science Ventures, Y Combinator and Oliver Cameron, who co-founded Voyage, the autonomous vehicle acquired by Cruise, also participated.

The carbon capture device is still in the prototype stage, Pereira said, with many specifics — such as the anticipated size of the end product and how long it will likely function — still to be worked out. Cost-effectively separating CO2 from the air is an extremely difficult problem to solve. The company is in the process of filing patents for the technology, so he declined to be too specific about many characteristics of the device, including what it will be made out of. But he did stress that the company is taking a fundamentally different technical approach to carbon capture.

“The current technologies, they are very complex. They are basically either [using] temperature or pressure [to capture carbon],” he said. “There is a lot of things that go into it, compressors, calciners and all these things,” referring to additional parts like mechanical pumps, cryogenic air separators and large quantities of water and energy. Pereira said the company will instead use electricity to control a chemical reaction that binds to the CO2. He added that Holy Grail’s devices are not dependent on scale to achieve cost reductions, either. And they will be modular, so they can be stacked or configured depending on a customer’s requirements.

The scrubbers, as Pereira calls them, will focus on raw capture of CO2 rather than conversion (converting the CO2 into fuels, for example). Pereira instead explained — with a heavy caveat that much about the end product still needs to be figured out — that once a Holy Grail unit is full, it could be collected by the company, though where the carbon will end up is still an open question.

The company will start by selling carbon credits, using its devices as the carbon reducing project. The end goal is selling the scrubbers to commercial customers and eventually even individual consumers. That’s right: Holy Grail wants you to have your own carbon capture device, possibly even right in your backyard. But the company still likely has a long road ahead of it.

“We’re essentially shifting the scaling factor from building a very large mega-ton plant and having the project management and all that stuff to building scrubbers in an assembly line, like a consumer product to be manufactured.”

Pereira said many approaches will be needed to tackle the mammoth problem of reducing the amount of CO2 in the atmosphere. “The problem is just too big,” he said.

The story has been updated to reflect that Holy Grail is based in Mountain View, not Cupertino.

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