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Sano Genetics, a startup helping with Long COVID research, raises £2.5M in seed funding

Sano Genetics, a startup with a broad mission to support personalised medicine research by increasing participation in clinical trials, has raised £2.5 million in seed funding.

The round is led by Episode1 Ventures, alongside Seedcamp, Cambridge Enterprise, January Ventures and several Europe and U.S.-based angel investors. It adds to £500,000 in pre-seed funding from 2018.

Sano Genetics says part of the new capital will be to fund free at-home DNA testing kits for 3,000 people affected by Long COVID. It will also further invest in the development of its tech platform and grow the team.

Founded in 2017 by Charlotte Guzzo, Patrick Short and William Jones after they met at Cambridge University while studying genomics as postgrads, Sano Genetics has built what it describes as a “private-by-design” tech platform to help patients take part in medical research and clinical trials. This includes at-home genetic testing capabilities, and is seeing the company support research into multiple sclerosis, ankylosing spondylitis, NAFLD and ulcerative colitis2, with a research programme for Parkinson’s disease on the agenda for later in 2021.

“For participants in medical research, the process is not user friendly,” says Sano Genetics CEO Patrick Short. “There is usually little to no benefit for participants beyond altruism, taking part is difficult and time-consuming and people are also concerned about the privacy of their sensitive genetic and medical information.

“[Therefore], for researchers in biotech, pharma and academia, it is very difficult to attract and retain research participants, which adds substantial costs and time to their research. In particular for research involving genetics and precision therapies, it is doubly challenging to find the ‘right’ patients because genetic testing is not routine in the healthcare system”.

To help solve this, Sano Genetics matches relevant participants to research via its platform. It then makes participation easier by enabling at-home genetic testing and by guiding participants through the process.

“The system is designed so users know exactly what will happen with their data, and we give them straightforward ways to control their data,” explains Short. “We keep our users engaged and involved in the research process by giving them updates on the research they have been a part of, and with free personalised content including genetic reports, and stories from other people like them on our blog”.

A typical end user is someone who has a chronic or rare disease and is using the platform to take part in research that helps them personally (e.g. access to a new therapy via a clinical trial) or to help others like them.

Meanwhile, Sano Genetics generates revenue by charging biotech and pharma companies fees to find the right patients for their studies. “The typical study for us consists of a set-up fee, a per-test fee for our at-home genetic testing and analysis, and a fee for each referral we make of an interested and eligible participant to their research study,” adds the Sano Genetics CEO.

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Driving down the cost of preserving genetic material, Acorn Biolabs raises $3.3 million

Acorn Biolabs wants consumers to pay them to store genetic material in a bet that the increasing advances in targeted genetic therapies will yield better healthcare results down the line.

The company’s pitch is to “Save young cells today, live a longer, better, tomorrow.” It’s a gamble on the frontiers of healthcare technology that has managed to net the company $3.3 million in seed financing from some of Canada’s busiest investors.

For the Toronto-based company, the pitch isn’t just around banking genetic material — a practice that’s been around for years — it’s about making that process cheaper and easier.

Acorn has come up with a way to collect and preserve the genetic material contained in hair follicles, giving its customers a way to collect full-genome information at home rather than having to come in to a facility and getting bone marrow drawn (the practice at one of its competitors, Forever Labs) .

“We have developed a proprietary media that cells are submerged in that maintains the viability of those cells as they’re being transported to our labs for processing,” says Acorn Biolabs chief executive Dr. Drew Taylor.

“Rapid advancements in the therapeutic use of cells, including the ability to grow human tissue sections, cartilage, artificial skin and stem cells, are already being delivered. Entire heart, liver and kidneys are really just around the corner. The urgency around collecting, preserving and banking youthful cells for future use is real and freezing the clock on your cells will ensure you can leverage them later when you need them,” Taylor said in a statement.

Typically, the cost of banking a full genome test is roughly $2,000 to $3,000, and Acorn says they can drop that cost to less than $1,000. Beyond the cost of taking the sample and storing it, Acorn says it will reduce to roughly $100 a year the fees to store such genetic materials.

It’s important to note that healthcare doesn’t cover any of this. It’s a voluntary service for those neurotic enough or concerned enough about the future of healthcare and their potential health. 

There’s also no services that Acorn will provide on the back end of the storage… yet.

What people do need to realize is that there is power with that data that can improve healthcare. Down the road we will be able to use that data to help people collect that data and power studies,” says Taylor. 

The $3.3 million the company raised came from Real Ventures, Globalive Technology, Pool Global Partners and Epic Capital Management and other undisclosed investors.

“Until now, any live cell collection solutions have been highly expensive, invasive and often painful, as well as being geographically limited to specialized clinics,” said Anthony Lacavera, founder and chairman at Globalive. “Acorn is an industry-leading example of how technology can bring real innovation to enable future healthcare solutions that will have meaningful impact on people’s wellbeing and longevity, while at the same time — make it easy, affordable and frictionless for everyone.”

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Nutrigene wants to personalize your vitamins using your genetic code

Vitamins are proving to be a lucrative industry in the United States. Just last year vitamin sales pulled in roughly $37 billion for the U.S. economy. That’s up from $28 billion in 2010. To cash in on this growing market, several startups have popped up in the last few years — including Nutrigene, a startup combining the vitamin business with another lucrative avenue of revenue in consumer DNA analysis.

Nutrigene believes your genes may hold the secret to what you might be missing in your diet. The company will send you tailor-made liquid vitamin supplements based on a lifestyle quiz and your DNA. You get your analysis by filling out an assessment on the startup’s website, choosing a recommended package such as “essentials,” “improve performance” or “optimize gut health.” After that you can also choose to upload your DNA profile from 23andMe, then Nutrigene will send you liquid supplements built just for you.

Founder Min FitzGerald launched the startup out of Singularity and later accepted a Google fellowship for the idea. Nutrigene then went on to Y Combinator’s winter 2018 class. FitzGerald’s co-founder and CTO Van Duesterberg comes from a biotech and epigenetics background and holds a PhD from Stanford.

PhDs and impressive resumes aside, the vitamin and genetics industries are not without controversy. For every study showing that those who eat a balanced diet don’t benefit from supplements, there are just as many highlighting the benefits of taking your vitamins. Also, coupling vitamin therapy with your DNA seems at a glance dubious. However, Dawn Barry, former VP at Illumina and now president of Luna DNA, a biotech company powered by the blockchain, says it could have some scientific underpinnings. But, she cautioned, nutrigenetics is still an early science.

Amir Trabelsi, founder of genetic analysis platform Genoox, agrees. We interviewed both Trabelsi and Barry previously when Nutrigene first came on our radar. Trabelsi pointed out these types of companies don’t need to provide any proof.

“That doesn’t mean it’s completely wrong,” he told TechCrunch. “But we don’t know enough to say this person should use Vitamin A, for example… There needs to be more trials and observation.”

Nutrigene acknowledges the best supplementation for performance goes beyond just a genetic profile. Our lifestyles, where we live, what we do and what we put in our bodies (or don’t) all can contribute to a deficiency. For better nutritional accuracy, Nutrigene will send you a blood test kit in the mail to test for things like Vitamin D deficiency (a common deficiency in Silicon Valley, according to my doctor). You also can choose to go to a blood testing center to find out what sort of nutritional supplements you’ll need for optimal performance.

One other twist — Nutrigene’s vitamins come in liquid form for what FitzGerald says is the optimum delivery method.

I tried out the program for myself earlier this year, though not for more than a few days as I was pregnant at the time and wanted to stick with the prenatal vitamins I’d been taking. Nothing I saw on the packaging from Nutrigene was dangerous for pregnant women, just run-of-the-mill stuff like vitamin B12, which my genetic analysis said I was prone to be deficient in. But I had already been taking some pretty good prenatal vitamins from New Chapter and a DHA supplement from Nordic Naturals for a year leading up to getting pregnant. I had a very healthy, nearly 9.5 pound baby boy in March. My own doctor, who tested my nutritional levels at the beginning of my pregnancy through a blood sample, did not tell me I had any deficiencies.

That’s not to say it wouldn’t be great for someone else looking for optimal nutrition and wanting a boost through supplementation. It’s also a great industry to get into if you know how to market your products. Though crowded, there’s plenty of room to grow and billions of dollars in the vitamin industry for those who can make their products stand out. DNA analysis and liquid supplementation might just be the thing.

FitzGerald tells TechCrunch that Nutrigene has already shipped 8,500 personalized dosages to customers since launching earlier this year.

For those interested in trying out Nutrigene, you can do so by ordering on the website. Package pricing varies and depends on nutritional needs, but starts at around $85 per month.

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Human sequencing pioneer George Church wants to give you the power to sell your DNA on the blockchain

 The blockchain is the buzziest thing on the internet these days and now MIT professor and godfather of the Human Genome Project George Church wants to put your genes on it. His new startup Nebula Genomics plans to sequence your genome for less than $1,000 and then add your data to the blockchain through the purchase of a “Nebula Token.” Read More

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Genetics startup Twist Bioscience is working with Microsoft to store the world’s data in DNA

DNA lab Twist Bioscience, a startup making and using synthetic DNA to store digital data, just struck a contract with Microsoft and the University of Washington to encode vast amounts of information on synthetic genes. Big data means business and the company able to gather a lot of it is very valuable to investors and stockholders. But that data needs to be stored somewhere and can cost a lot for… Read More

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