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Cervest raises £3.7M for Earth Science AI platform to predict climate effects

Climate risk, including extreme events and the related pressures our environment, are fundamentally affecting the way businesses and governments operate — both tactically and strategically. Increasing climate volatility is causing food supply disruptions and increasing pressure on Enterprises (including financial institutions, insurers and producers) to disclose what’s going on.

The trouble is, while there is a lot of data about all this, its complexity, incompleteness and sheer volume is too vast for humans to process with the tools available today. So just as the climate changes, we are faced with “data chaos.” Equally, other parts of the world suffer from data scarcity, making it much harder to provide useful and timely analysis.

So the challenge is to address these issues simultaneously. So a new startup, Cervest, has created an AI-driven platform designed to inform the decision-making capabilities of businesses, governments and growers in the face of increasing climate volatility.

Cervest, has now closed a £3.7 million investment round to fund the launch of its real-time, climate forecasting platform.

The round was led by deep-tech investor Future Positive Capital, with co-investor Astanor Ventures . The seed-stage funding round brings the company’s total funding to more than £4.5 million.

Built on three years of research and development by a team of scientists, mathematicians, developers and engineers, Cervest says its Earth Science AI platform can analyze billions of data points to forecast how changes in the climate will impact the future of entire countries, right down to individual landscapes.

It does this by combining research and modeling techniques taken from proven Earth sciences — including atmospheric science, meteorology, hydrology and agronomy — with artificial intelligence, imaging, machine learning and Bayesian statistics.

Using large collections of satellite imagery and probability theory, the platform can identify signals, or early-warning signs, of extreme events such as floods, fires and strong winds. It also can spot changes in soil health and identify water risk.

Cervest says the platform could do such things as reveal the optimum location to build a new factory; warn a wheat grower that their crop yield isn’t expected to meet its targets; or be used by insurers to help them set premiums for the next 12 months.

The team comes from a network of more than 30 universities, including Imperial College, The Alan Turing Institute, Cambridge, UCL, Harvard and Oxford, and has published more than 60 peer-reviewed scientific papers.

A beta version of the platform is due to launch in Q1 2020.

Iggy Bassi, founder & CEO, Cervest said: “Our goal is to empower everyone to make informed decisions that improve the long-term resilience of our planet. Today decision-makers are struggling with climate uncertainty and extreme events and how they are affecting their business operations, assets, investments, or policy choices.”

Sofia Hmich, founder, Future Positive Capital said: “With reports suggesting we have fewer than 60 years of farming left unless drastic action is taken, the need for science-backed decisions could not be greater. Businesses and policymakers hold the key to change and with access to Cervest’s proprietary AI technology they can start to make that change a reality at low cost — before it’s too late.”

Bassi previously ran the impact-led agribusiness GADCO, which was supported by Acumen Fund, Soros, Gates Foundation, World Bank and Syngenta . Its impact was featured in UNDP, World Economic Forum, FT, The Guardian and Huff Post. He previously built a software company focused on data analytics.

Cervest was inspired by Bassi’s experience building a farm-to-market agribusiness whilst confronting first-hand the impacts of climate and natural resource volatilities.

The Cervest team includes eight scientists and four PhDs. Between them, they have published more than 60 peer-reviewed scientific papers with more than 3,000 citations in high-profile titles, including Nature, Proceedings of the National Academy of Sciences and The Royal Statistical Society.

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As biological manufacturing moves to the mainstream, Synvitrobio rebrands and raises cash

The pace at which the scientific breakthroughs working to bend the machinery of life to the whims of manufacturing have transformed into real businesses has intensified competition in the biomanufacturing market.

That’s just one reason why Synvitrobio is rebranding as it takes on $2.6 million in new financing to pursue opportunities in biopharmaceutical and biochemical manufacturing. Under its new name, Tierra Biosciences, the company hopes to emphasize its focus on agricultural and biochemical products.

The company is one of several looking to commercialize the field of “cell-free” manufacturing — where biological engineers strip down the cellular building blocks of life to their most basic components to create processes that ideally can be more easily manipulated to produce different kinds of chemicals.

There’s a standard way to create these cell-free processes (described quite nicely in The Economist).

Grab a few quarts of culture with some kind of bacteria, plant or animal cells in it. Then use pressure to force the cells through a valve to break up their membranes and DNA. Give the goo a nice warm environment heated to roughly the average temperature of a human body for about an hour. That activates enzymes that will eat the existing DNA.

Put all of it in a centrifuge to separate out the ribosomes (which are the important bits). Take those ribosomes and give them a mixture of sugars, amino acids, adenosine triphosphate (the molecular compound that breaks down to provide energy for all biological functions) and new DNA with a different set of instructions on what to make and voila! Micro-factories in a test tube.

Along with co-founders Richard Murray of the California Institute of Technology and George Church, one of the living legends of modern genetics, chief executive officer Zachary Sun designed Tierra to be an engine for new biochemical discovery.

“Everything floats in the cytoplasm… We keep that internal stuff and that allows us to run reactions where a cell wall isn’t necessary. I want to reduce the complex system down to its component parts,” says Sun. “We look at this as a data collection problem. We want to use cell-free to tell you what to put either in a cell or in cell-free systems… We can collect more data faster using our cell-free system.”

The startup is already working with the Department of Energy research institution at Oak Ridge National Laboratory to develop processes to create vanillin (vanilla extract) and mevalonate (turpentine) from biomass.

It’s an approach that is already showing the potential for investment returns in life sciences and pharmaceuticals. For inspiration, Tierra can look to the South San Francisco-based Sutro Biopharma.

That company has signed a drug discovery agreement with Merck to develop new immune-modulating therapies (that bring the immune system into check) for cancer and auto-immune disorders, in a deal worth up to $1.6 billion if the company hits certain milestones — in addition to a $60 million upfront payment. Sutro raised more than $85 million in new funding in July (from investors including Merck) and just filed to go public on the Nasdaq.

According to Sun, the newly named Tierra has its own partnerships with global 2,000 companies in the works. “We’re looking to scale those commitments. We see the application space as being this natural products environment,” he says.

There’re multiple avenues to pursue, with the technology widely applicable to everything from pesticides to pharmaceuticals, flavorings and even energy.

Cyclotron Road team photos. 2016. Zachary Sun.

“Synthetic biology at its core is about applying engineering best practices to speed up the ‘design-build-test’ cycles in the reprogramming of existing or construction of new biological systems. By component-izing and modularizing the cell they can radically increase the speed of those cycles,” says Seth Bannon, a co-founder of the venture capital firm Fifty Years, which invests in startups commercializing “frontier” science. 

For the investors, entrepreneurs and reporters who witnessed the birth of the cleantech bubble a decade ago and then tracked its implosion in subsequent years, the excitement this kind of technology elicits is another of history’s rhymes.

Technologies like Tierra’s aren’t new. San Diego-based Genomatica has been working on biological manufacturing for the past 18 years. The company is now exploring a cell-free system to grow chemicals that are used in the manufacture of materials like Lycra. Since 2008, Medford, Mass.-based GreenLight Biosciences has been working to bring its own biologically based zero-calorie sugar substitute to market.

What may be different now is the maturity of the technologies that are being commercialized and the perspective of the startups coming to market — who have the benefit of avoiding the missteps made by an earlier generation.

Investors led by Social Capital with participation from Fifty Years, KdT Ventures and angel investors seem to see a difference in these companies. And large research institutions are also marshaling resources to support the vision laid out by Sun, Murray and Church. DARPA, the National Institutes of Health, the Department of Energy, Cyclotron Road and Lawrence Berkeley National Laboratory, the National Science Foundation and the Gates Foundation have all backed the company, as well.

“So many therapeutic molecules come from nature. As the DNA of plants, animals and microbes is read in exponentially increasing volume, we expect to find useful and game-changing chemistry encoded by it. Tierra’s platform will allow us to look for molecules which might otherwise be buried in the complexity of cells’ metabolism,” says Louis Metzger, chief scientific officer of Tierra, who comes from a background of drug discovery.

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DFS Lab is helping the developing world bootstrap itself with fintech

Entrepreneurs have it rough in Africa, India, Pakistan — places where VC cash doesn’t fall from the sky and necessary infrastructure like reliable banking and broadband can be hard to come by. But companies grow and thrive nevertheless in these rugged environments, and DFS Lab is an incubator focused on connecting them with the resources they need to go global.

The company was founded, and funded, on the back of a $4.8 million grant from the Gates Foundation, which of course is deeply concerned with tech-based solutions for well-being all over the world. Its name, Digital Financial Services Lab, indicates its area of focus: fintech. And anyone can tell you that sub-Saharan Africa is one of the most interesting places in the world for that.

This week DFS Lab is announcing a handful of new investments — modest ones on the scale companies are used to in Silicon Valley, but the money is only a small part of the equation. Investment comes at the end of a longer process, the most valuable of which may be the week-long sprint DFS Lab does on the ground, helping solidify ideas into products, or niche products into products at scale.

The relative lack of VCs and angel investors puts early-stage companies at risk and can discourage the most motivated entrepreneur, so the program is aimed at getting them over the hump and connected to a network of peers.

The latest round puts a total of $200,000 into four startups, each touching on a different aspect of a region or vertical’s financial needs. All, however, are largely driven by the massive growth of mobile money in Africa over the last decade and the more recent, ongoing transition to modern smartphones and the app/data landscape familiar to the U.S. and Europe.

  • Nala aims to move p2p payments away from the antiquated but widely used USSD system (more on this later) to a Venmo-like app interface that integrates multiple native mobile currencies like M-Pesa into a single tool.
  • Cherehani connects female entrepreneurs with financial resources; the idea is to provide both much-needed credit and financial literacy at as early an age as possible. (They have a chatbot too, naturally.)
  • Nobuntu is a platform through which South Africans can open and contribute to pension plans via mobile money, simply and with low overhead costs.

The fourth company is choosing to remain in stealth mode for now, but you see the general theme here.

For one reason or another there are major gaps in everyday services that many of us take for granted — the ability to prove one’s identity, for example, is critical but commonly absent. I talked with Paul Damalie, founder of a DFS-funded company called Inclusive that helps address that particular shortcoming.

Basic ID verification can be difficult when you remove many of the things we take for granted. So when, for example, someone wanted to get a loan, a savings account, or some other basic financial service, “Originally you’d have to literally walk into the bank to do it,” Damalie said. Needless to say that isn’t always convenient, and banks as well as users want better options.

“We’ve been collecting existing databases and building a layer of rich access around it,” he continued. “Now we can use facial recognition to check those details. Once you have the ID, you need to check it with the government records” — which Inclusive also does. A range of other data creates a confidence score in the person’s identity, helping avoid identity fraud.

Another opportunity arises not from these gaps but from the unique ways in which the African ecosystem has evolved. USSD, which I mentioned before, is probably unknown to many of our readers — it certainly was to me. But it’s become a standard tool used regularly by millions for important tasks in Africa; if you want to work in that market, you have to deal with USSD one way or another.

The problem is that, as you might guess from Nala trying to deprecate it, USSD is a technology dating back to the ’90s, a text-based interface that’s rudimentary but, much like SMS, universally accepted and intelligible. The importance of cross-platform compatibility in mobile markets as fragmented as these can’t be overstated.

So bridging the gap between USSD and a “traditional” (as we might call it) payment app is a unique opportunity, and one a company called Hover (also in the DFS Lab portfolio) is addressing. Its tech acts as a sort of translation layer between USSD and smartphone app interfaces, allowing for modern app design but also deep back-compatibility. It’s an opportunity specific to this time and this area of the world, but nevertheless one that may end up touching millions.

And from the narrowness of its vision that DFS Lab derives its effectiveness.

“They’re one of the most specialized accelerators in the world,” said Damalie. “It goes beyond just funding — it involves having the right kind of network: access to partners, data, sources across the continent. They had context-relevant fellows, people who had very specific challenges.”

“The grant was useful and let us build a proof of concept, and of course the Gates Foundation gives us credibility. But they were taking bets on us as individuals.”

Although DFS Lab has heretofore been funded by the Gates infusion, that well will run dry soon. Jake Kendall, DFS Lab’s executive director, indicated that the plan is to move towards a more traditional investor fund. They already focus on profitability and the potential for growth to the continental stage or beyond; this isn’t a charity but tactical investment in such a way that social good is a necessary byproduct.

“The best way to have a global impact is to be self-sustaining,” he said.

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